Antibacterial Effect Of Fosfomycin Tromethamine On The Bacteria Inside Urinary Infection Stones

Urinary stone represents one of the most common urological diseases.Clinically,patients who have reached the indications for surgery are treated with endoscopic techniques.However,more and more cases of postoperative infections are caused by this.Therefore,it is necessary to find a new perioperative antibiotic for urinary stones.Fosfomycin,an ancient antibiotic,has become an alternative antibiotic for urinary tract infections due to its extremely high sensitivity and low resistance to most Gram-positive / negative bacteria.And there has been expert consensus that fosfomycin can be used as an antibiotic of choice for upper urinary calculus surgery.However,there is currently no data on the use of fosfomycin for perioperative infection in urinary stones.This study intends to study the antibacterial effect of fosfomycin tromethamine on bacteria inside urinary infectious stones,and explore its possibility as an perioperative antibiotic for urinary stones.ObjectiveDetecting the concentration of fosfomycin and cefuroxime and the bacterial count in urinary stones,as well as the clinical infection index of patients.To evaluate the antibacterial efect of fosfomycin tromethamine(FT)on the bacteria inside urinary infection stones.Methods1.Scanning electron microscope was used to observe the inside of infectious stones.2.Randomly assigning equal numbers of patients with kidney stones who met the inclusion criteria into two groups in a prospective study and treated them with diferent perioperative antibiotics.One group was treated with FT,and the other was treated with cefuroxime sodium.All stone specimens were collected via percutaneous nephrolithotomy(PCNL).3.The primary infection stones were screened via a stone component analysis.4.High-performance liquid chromatography(HPLC)-mass spectrometry was used to measure the drug concentration inside the stones.5.The bacterial count was calculated via stone culture.6.Monitoring the clinical infection index.Results1.A large number of bacteria are present inside infectious stones.2.Compared with the control group,the experimental group had a higher internal drug concentration,a lower MIC(Minimum inhibitory concentration),a higher drug sensitivity against various pathogenic bacteria.3.Compared with the control group,the experimental group had a lower positive rate and bacterial colony count in the stone culture.4.Compared with the control group,the experimental group hadand a lower incidence of postoperative infection and sepsis.ConclusionsFT is more effective than cefuroxime,which is commonly used during the perioperative period of urinary stones,and exerts a high antibacterial effect on these internal bacteria,and efectively reduces the probability of infection and sepsis after urinary stone surgery.FT can be used as an antibiotic during the perioperative period of urinary stones.