| Alzheimer disease(AD)is a neural degenerative disorder.There is no effective treatment currently.Revealing the pathogenesis of AD is crucial for the development of effective therapies and drugs.In this paper,the changes of spatial working memory and the abnormity of the field potential oscillations in the ventral hippocampus(vHPC)and medial prefrontal cortex(mPFC)have been mainly studied in 3×Tg-AD mice(AD model mice)by using in vivo multi-channel electrophysiological recording technique.The main findings of this paper are as follows: 1.When 3×Tg-AD mice move freely in the familiar environment,the power of the delta oscillations decreases and that of the theta and gamma oscillations abnormally increases in vHPC and mPFC respectively.Besides,the information integration in vHPC and the information transfer from vHPC to mPFC are impaired.2.3×Tg-AD mice show a significantly lower motivation to explore in a novel environment.When exploring,the power of the delta oscillations decreases in vHPC and mPFC and that of the high gamma oscillations abnormally increases in mPFC of 3×Tg-AD mice.In addition,the information integration and transfer in/between their vHPC and mPFC are impaired in 3×Tg-AD mice.3.Spatial working memory is impaired in 3×Tg-AD mice.Sharp wave ripple in vHPC is significantly weaker,the alteration of gamma oscillations is abnormal and the information integration in vHPC and mPFC and the information transfer from vHPC to mPFC are impaired during the spatial information maintenance phase in 3×Tg-AD mice.Besides,the power of theta oscillations decreases abnormally in vHPC and the theta synchrony is impaired between vHPC and mPFC during the choice phase of spatial working memory task in 3×Tg-AD mice.Based on the above results,it can be concluded that the abnormal neural oscillations and the impairment of the information integration and transfer in/between the vHPC and mPFC are probably the neural mechanism of spatial working memory impairment in 3×Tg-AD mice. |
PDF Full Text Request