| Orofacial pain disorders are common in today’s population and compromise the quality of life of the sufferer.Several studies have shown that cannabinoids produced significant analgesia in the orofacial pain.Opioids have been used for long time to manage the pain and continue to be one of the most commonly prescribed drugs for pain relief.The aim of present study was to investigate the interaction between fentanyl and WIN 55,212-2 that produced robust analgesia in acute and inflammatory pain models,on formalin-induced orofacial pain.Our results showed that formalin injection caused significant spontaneous pain behaviors and increased the expressions of the cFos in the ipsilateral trigeminal ganglion(TG).All of the fixed-ratio combinations tested produced greater antinociception than predicted from simple additivity.Four hours after formalin injection,the level of c-Fos immunoreactivity in the ipsilateral TG neurons was much lower in mice pretreated with the control group.These findings suggest that the use of a low-dose combination of fentanyl and WIN 55,212-2 is a valid and effective approach for the treatment of oralfacial pain. |
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