Effects Of Desflurane And Propofol On Arterial Oxygenation And Complications In Patients Undergoing One-lung Ventilation

Objective The aim of this study is to compare the effects of de sflurane and propofol on intraoperative oxygenation and postoperative complications in patients undergoing one-lung ventilation,to investigat e advantages and disadvantages of the two kinds of anesthetics,then t o provide reasonable reference for clinical anesthesia.Methods 60 patients scheduled for thoracoscope surgery,aged 30-70years old,ASA grade?-?,body weight 40-80 kg,were randomly di vided into two groups:desflurane group?group D n=30?and propofol group?group P n=30?.Anesthesia induction:Intravenous injection of mi dazolam 0.05-0.1mg/kg,sufentanil 0.4-0.5ug/kg,etomidate 0.2-0.4mg/kg,a nd rocuronium 0.8-1mg/kg.Anesthesia maintenance:6-8%desflurane wa s inhaled to maintain 1.0-1.5 MAC in group D,and continuous intrav enous Propofol infusion at 4-12mg/kg/h in group P.Blood of the radi al artery was collected before anesthesia induction?T₀?,30 minutes aft er one-lung ventilation?T₁?,and 60 minutes after one-lung ventilation?T₂?for blood gas analysis,then calculated oxygenation index.Incidence of Clavien-Dindo grade II-V complications during hospitalization was recorded.Results There were no significant differences between two group s in general information,side of endobronchial tube,surgery time,OLV time,blood loss and the volume of fluid transfusion?P>0.05?.Comp ared with T₀,OI decreased significantly at T₁ and T₂ in two groups?P<0.05?.For OI at the same time point,there was no significant diff erence between two groups?P>0.05?.There were no significant diff erences between two groups in the incidence of postoperative complic ations and the duration of postoperative hospitalization?P>0.05?.Conclusion Compared with propofol,desflurane has no advantag e in maintaining intraoperative oxygenation and reducing postoperative short-term complications.Both anesthetics can be confidently used in one-lung ventilation.