Clinical Study On Treatment Of Cervical Human Papilloma Virus Infection With Taraxacum Extract For Vagina

Part one Analysis of Human Papilloma Virus subtypes in cervical cells of 26385 gynecological outpatientsObjective:To analyze the prevalence and subtypes of human papilloma virus(HPV)infection in gynecological outpatients of Hebei genernal hospital.Methods:From April 2014 to August 2017,a retrospective analysis was made of 26385 patients who received HPV test in the gynecological clinic of the hospital.According to the age stage,the patients were divided into five groups:1792 in the 15?25-year-old group,7974 in the 26?35-year-old group,8178 in the 36?45-year-old group,6055 in the 46?55-year-old group and 2386in the 56 year-old group.The infection rate and distribution of different subtypes of HPV in five groups were analyzed.Results:Among the 26385cases,the positive rate of HPV was 33.05%(8719/26385),including 6992cases of high-risk infection,784 cases of low-risk infection and 943 cases of high-risk mixed infection.There were 12901 cases of HPV infection in total,including 11059 cases of high-risk HPV infection,accounting for 91.46%,the most common subtypes were HPV16,HPV58,and hpv52.The infection rate of each age group was different(?2=42.198,P<0.01),the highest age group was 15-25 years old,and the second age group was?56 years old.The difference was statistically significant compared with other age groups(?2=203.281,P<0.01;?2=42.033,P<0.01).Conclusion:The HPV infection rate was higher in the hospital,mainly with a high-risk HPV infection,and the main infection was HPV16,HPV58 and HPV52.The infection rate of HPV in the age group of 15-25 and?56 years old is relatively high,so the clinical prevention and screening measures should be taken.Part two Study on preparation technology of dandelion extract for vaginaObjective:optimize the preparation process of dandelion preparation and prepare vaginal dandelion preparation.Methods:The content of the effective components in the extract and the formability,hardness and homogeneity of the preparation were used as the evaluation indexes to determine the alcohol precipitation concentration,the types and doses of the auxiliary materials in the preparation process of vaginal dandelion traditional Chinese medicine preparation.Results:The optimum concentration of the water extract of dandelion was 60%alcohol,and the appropriate excipients of the extract were propylene glycol and polyethylene glycol 6000,with a ratio of 32:1:7.Conclusion:The preparation method is simple and feasible,the properties of the preparation are stable,its microbial limit test and content determination meet the standards,and it can be used in clinical researchl.Part three Observation on the therapeutic effect of dandelion preparation in vagina on cervical HR-HPV infectionObjective:To explore the clinical effect of dandelion preparation for vagina in the treatment of cervical HR-HPV infection.Methods:From November2018 to June 2019,63 patients with cervical HR-HPV infection diagnosed in the gynecological outpatient department of Hebei genernal hospital were randomly divided into treatment group and control group.The patients in the treatment group were treated with dandelion preparation,and the patients in the control group were treated with Recombinant Human?-2b Interferon Capsule for Vaginal Foams.To compare the clinical effect of the two groups.Results:Both groups can reduce the clinical symptom score of patients(Z treatment group=-3.740,P=0.00;Z control group=-3.619,P=0.00);In the treatment group,the negative conversion rate of patients under 30 years old is the highest,which is statistically significant compared with other age groups(?~2=8.068,P=0.018).In the control group,the negative rate of patients under 30years old was the highest,which is no statistically significant compared with other age groups(?~2=3.768,P=0.152).For HPV16 and HPV18,the negative rate in the treatment group was higher than that in the control group,the difference was not statistically significant(?~2=0.268,P=0.605).The total effective rate of the treatment group was better than that of the control group,the difference was not statistically significant(?~2=0.032,P=0.859).Conclusion:Dandelion preparation has a certain potential value in the treatment of cervical HR-HPV infection,especially for patients under 30 years old,which can be the next research direction..