Analysis Of Neutrophil/lymphocyte Ratio And Platelet/lymphocyte Ratio Levels In Hypertensive Patients With OSAS

Objective: By examining the changes of neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR),exploring the mecha nism of obstructive sleep apnea syndrome(OSAS)leading to the d evelopment of hypertension.Methods:This study retrospectively analyzed 119 patients who underwent overnight polysomnographic sleep monitoring in our hospital from July 2018 to November 2019,and collected clinical data based on whether they had hypertension and sleep apnea hypopnea index(AHI).Divided into 3 groups:(1)27 patients in OSAS group with AHI?5 and no history of hypertension;(2)34 patients in simple hypertension group with AHI?5 and history of hypertension;(3)58 patients with hypertension combined with OSAS group with AHI?5 and history of hypertension.The blood routine,blood biochemical parameters,and sleep-related parameters of patients were counted.SPSS software was used to calculate and analyze whether there were statistical differences in NLR and PLR between the three groups,and to analyze the correlation between NLR,PLR and AHI.Binary logistic regression to analyze the risk factors of hypertension in OSAS patients.Results:1.The NLR value of the hypertension combined with OSAS group was significantly higher than that of the simple hypertension group and the simple OSAS group(P <0.05),and there was no statistical difference in PLR between the groups.2.NLR was positively correlated with AHI(r = 0.186,P <0.05)and oxygen desaturation index(ODI)(r = 0.202,P <0.05).3.NLR can predict the occurrence of hypertension in OSAS patients,and its area under curve(AUC)is 0.672(P <0.05).Conclusions:NLR levels in patients with hypertension and OSAS are higher than those in patients with hypertension and OSAS alone.OSAS may trigger the development of hypertension through inflammatory reactions.