Study On The Change Trend Of SAA And CRP In Children With Acute Upper Respiratory Infection And Its Clinical Significance

Objective:To verify the clinical predictive value of serum amyloid A?SAA?in the early stage of viral acute infection,and to achieve early and rapid detection of infection types.Method:Using the retrospective analysis method,we selected the children with acute upper respiratory tract infection who were hospitalized within 120 hours from October 2017 to May 2019 as the research object,and divided them into 100 cases of virus group and 200 cases of bacteria group.The serum SAA and C-reactive protein?CRP?contents were detected within24 hours,48 hours,72 hours,96 hours and 120 hours respectively 23.0software was used for intra group and inter group comparison.Result:1. The difference of SAA content between bacteria group and virus group was statistically significant?P<0.05?.Within 24-120 hours after infection,the SAA content of virus group was higher than that of bacteria group at the same time,P<0.05.2. The difference of CRP content between bacteria group and virus group was statistically significant?P<0.05?.Within 24-120 hours after infection,the CRP content of bacteria group was higher than that of virus group?P<0.05?.3. The SAA content of influenza A and B group and respiratory syncytial virus group were statistically significant?P<0.05?.There was significant difference in SAA content between the two virus groups with time?P<0.05?.Within 24-120 hours after infection,the SAA content of RSV group was lower than that of influenza A and B group?P<0.05?.4. The SAA content of the four types of bacteria was statistically significant?P<0.05?.However,there was no significant difference in SAA content between the bacterial groups over time?P>0.05?.5. The ROC curve of diagnosing virus infection showed that AUC_SAA/CRPSAA>CRP in specificity.Conclusion:1.SAA is a serological index that can be significantly increased in the early stage of virus infection and has diagnostic value,and its diagnostic value is better than CRP.2.The combination of SAA and CRP has the highest diagnostic reference value for viral infection,which is conducive to the early simple and more accurate identification of the type of infection.