| Objective: To explore the effect of hyperthermic intraperitoneal che motherapy on cellular immune function of postoperative patients with st age c T4 colorectal cancer by analyzing the relevant immune indexes of patients with stage c T4 colorectal cancer.These immune indexes were d etected during the period of postoperative patients who underwent hypert hermic intraperitoneal chemotherapy.Methods: Relevant clinical data of patients with colorectal cancer d iagnosed as c T4 during operation from October 2018 to September 2019 in our department were collected for retrospective study.The 75 patien ts were divided into experimental group(radical surgery and hypertherm ic intraperitoneal chemotherapy)with 35 patients and control group(radic al surgery)with 40 patients.Patients in the experimental group received hyperthermic intraperitoneal chemotherapy once every 24 hours after sur gery,for a total of 3 times.The basic clinical information(sex,age,bo dy mass index,tumor location,height and weight)of the two groups of patients were analyzed.The immune indexes(CD4+ cells,CD8+ cells,CD4+/CD8+ ratio),nutritional indexes(albumin,prealbumin)and inflam matory indexes(platelet/lymphocyte ratio,neutrophil/lymphocyte ratio,plat elet count,white blood cell count,neutrophil and lymphocyte count)of t he two groups were compared preoperative,on the 1st day postoperative and on the 5th day postoperative.In the above data,the counting data were analyzed by Chi-square test and measurement data were analyzed by T test.Results: There was no significant difference between the two group s in terms of sex,age,height,weight,BMI,tumor location and other b asic data before operation(P>0.05).The CD4+ cells,CD8+ cells,D4+/CD8+ ratio,albumin,prealbumin,platelet/lymphocyte ratio and neutrophil/lymphocyte ratio of patients preoperative were all within the normal ran ge,and the difference was not statistically significant(P>0.05).On the 1st day postoperative,the indexes of CD4+ cells,CD8+ cells,CD4+/CD8+ ratio,albumin,prealbumin,platelet/lymphocyte ratio,neutrophil/lympho cyte ratio and so on in the two groups have different degrees of chang es compared with those before operation,but there is no statistical signi ficance between the two groups(P>0.05).After 3 times of hyperthermic intraperitoneal chemotherapy,that is the 5th day after operation,CD4+ cells,CD4+/CD8+ ratio in the experimental group are higher than those in the control group,CD8+ cells are lower than those in the control g roup.The changes of CD4+ cells,CD8+ cells and CD4+/CD8+ ratio in the two groups have statistical differences(P<0.05).The related albumin and prealbumin in the experimental group were lower than those in th e control group(P<0.05),and the difference between albumin and prealb umin was statistically significant.However,there was no statistical diffe rence in all related inflammatory indexes(P>0.05).Conclusion: The dual effects of hyperthermic and chemotherapy of HIPEC do not aggravate the body's inflammatory reaction,but the appl ication of HIPEC will cause the decline of the body's metabolic capacit y.The application of HIPEC in the early postoperative period of c T4 c olorectal cancer will not further cause the disorder of the body's cellular immune function,but will cause the rise of the cellular immune functi on.Therefore,HIPEC is generally safe and feasible for early postoperati ve treatment of stage c T4 colorectal cancer.However,during treatment,attention should be paid to adjusting the perioperative nutritional status of patients and reducing the level of inflammation in order to improve and stabilize the immune function of patients,promote the smooth recov ery of patients and prevent tumor recurrence and metastasis. |
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