Correlation Between Skin AGEs And Bone Mineral Density And TCM Syndromes In Patients With Type 2 Diabetes

Objective: To observe the expression of skin AGEs in T2 DM patients with different bone mass;to explore the correlation between skin AGEs and T2 DM patient's bone mass;.In the end,to assess the reference value and clinical significance of skin AGEs as a predictor of DOP.Methods: A cross-sectional study was used to collect the cases of T2 DM patients admitted to the Endocrinology Department of Chengdu University of Traditional Chinese Medicine from October 2017 to October 2019 who met the inclusion criteria of this study and did not meet the exclusion criteria.A total of 371 cases were in this study after asking about medical history,collect relevant indicators and the four diagnosis data of traditional Chinese medicine.Group the skin AGEs cumulative quarterback,T2 DM and DOP TCM syndrome types,T2 DM with or without complications to analysis.This study applies SPSS 23.0 to analyze data.Results:1.Comparison of quarterback groups by skin AGEs:1.1 There were differences in FN BMC and FN a BMD between groups;1.2 There were statistical differences in the presence of diabetic peripheral neuropathy,cardiovascular disease and smoking,whether there were prostate hyperplasia in male patients is also different between groups;2.The cumulative value of skin AGEs is significantly different between T2 DM and with different bone mass groups;bone mass of T2 DM patients decreases with the accumulation of skin AGEs;3.Correlation analysis: Skin AGEs are positively correlated with FPG,2h PBG,Age,Course,BUN,HCY,Cr,CYS-C,urine microalbumin,and negatively correlated with Alb,0h INS,1h INS,2h INS,3h INS,HOMA-IR,AUCins;4.The results of logistic regression analysis showed that: BMI is a protective factor for diabetic bone loss and DOP,course is an independent risk factor for diabetic bone loss;AGEs is an independent risk factor for DOP;5.ROC curve: The accumulated AUC of AGEs is 0.804(76%-84.9%),the corresponding accumulated AGEs value is 91.3,the sensitivity is 0.699,the specificity is 0.84.6.Comparison by T2 DM TCM Syndrome Groups:6.1 The composition ratio of syndrome types is as follows: Qi and Yin deficiency syndrome>Yin and Yang deficiency syndrome>Damp-heat-stagnation spleen syndrome>Blood-stasis and vein-collateral syndrome>Yin deficiency-heat syndrome;6.2 The AGEs,L1 a BMD,L2 a BMD,L3 a BMD,FN BMC,Age,Height,Course were statistically different between the groups;6.3 The risk factors of T2 DM TCM syndrome type were analyzed,the results showed that: FN BMC and L2 a BMD were independent risk factor for damp-heat-stagnation spleen syndrome;Sex and AGEs were risk factors for yin-yang deficiency and blood stasis.There were no correlation between the other types and the included indicators;7.Grouped by DOP TCM syndrome type: there is no statistical difference in general information;Conclusions:1.The bone mass of T2 DM patients decreases with the accumulation of skin AGEs,and skin AGEs are independent risk factors for DOP;2.Skin AGEs may be used as a predictor of DOP,it may be considered for clinical promotion;3.Assess of TCM syndrome types in patients with T2 DM from skin AGEs may be more meaningful in terms of deficiency of yin and yang,stop of blood stasis and water.