Clinical Study On The Distribution And Changes Of Syndrome Elements In 102 Patients With Stage ?A~?B NSCLC Before And After Gefitinib Treatment

Objective:Summarize the distribution characteristics of Syndrome Elements before and after Gefitinib treatment for NSCLC in stage ?A to ?B,to explore the changes of Syndrome Elements before and after Gefitinib treatment.Next,determine and prove that Gefitinib has the characteristics of four qi,five flavors,guijing,and ups and downs in TCM.The purpose is to provide a reference for treatment strategies,that is,TCM combined with Gefitinib for synergistic treatment,and actively take advantage of TCM.Methods:This study used a prospective study approach,A total of 102 patients with stage ?A to ?B NSCLC who met the inclusion exclusion criteria in the First Oncology Department,Second Oncology Department,Respiratory Department,the Affiliated Hospital of Chengdu University of TCM from December 2018 to February 2020 were selected,recorded TCM sights,smells,questions,pulses and other related information of patients before and after Gefitinib treatment 3 days and 15 days after treatment,extracting TCM Syndrome Elements.Then established a database,and used the SPSS statistical software to analyze the distribution characteristics and changes of syndrome elements before and after Gefitinib treatment.Results:1.Common symptoms in patients with stage ?A to ?B NSCLC are: cough,sputum thick,white sputum,yellow sputum,chest tightness,greasy tongue,slippery pulse,white tongue fur,pulse count,and thin pulse.After treatment with Gefitinib,the symptoms such as cough,thick sputum,white sputum,white tongue coating,and slippery pulses were reduced compared with before treatment,With the Chisquare test,there are no significant difference in the distribution of the syndromes listed earlier(P > 0.05).Significantly increased symptoms include prolonged lack of appetite,fatigue,fatigue,paroxysmal heat,less thick sputum,yellow tongue coating,peeling / less / none,pulse count,Chi-square test showed significant differences in the distribution of the above syndromes(P<0.05).New symptoms after Gefitinib treatment include rash,erythema,itching of the skin,frequent diarrhea,nausea,and vomiting.2.The main disease location Syndrome Elements before treatment with Gefitinib were lung and spleen,and the main disease site syndromes after treatment were lung,spleen,stomach and skin.After Gefitinib treatment,the symptoms of lungs decreased and spleen increased.Chi-square test showed that they had significant differences(P < 0.05).Symptoms of emerging disease location are skin,stomach.3.The main symptomatic elements of Gefitinib before treatment are: sputum > Qi deficiency > heat > blood stasis > Yin deficiency > cold;the main symptomatic elements of Gefitinib after treatment are: sputum > heat > blood stasis > Qi deficiency > Yin deficiency > Wet.Symptoms of disease location before and after treatment are sputum,Qi deficiency,heat,blood stasis,and Yin deficiency,and their distributions are significantly different by chi-square test(P<0.05).Conclusions:1.Significant differences in lung,skin,spleen,Qi deficiency,heat,sputum,and Yin deficiency are found before and after treatment with Gefitinib for NSCLC in stage ? A to IVB.Lung and sputum are significantly reduced after treatment.Skin,spleen,and Qi deficiency,Heat,and Yin deficiency increased significantly after treatment.2.Gefitinib's traditional Chinese medicinal flavor attributes are: warm nature,flavor belongs to Xin,meridians belong to Lung meridian,control ascension.