| Objective: To detect peripheral blood cells and humoral immune function indicators of patients with peptic ulcer(PU)and patients with essential hypertension(EHT),observe changes in the overall immune function indicators of the two,and further analyze different conditions(H.pylori infection,EHT course,etc.),the immune function of the two is changed,and the prognosis of upper gastrointestinal bleeding(UGIB)in both is explored.Methods: 110 cases of PU patients with EHT who were treated in the department of gastroenterology of the Affiliated Hospital of Hangzhou Normal University from June 2018 to December 2019 were selected as the study group,of which 55 cases were Helicobacter pylori(H.pylori)infection,37 cases had UGIB,49 cases had poor blood pressure control and 61 cases had good control,54 cases had EHT with a course of more than 10 years and 56 cases had less than 10 years of disease.In the same period,117 cases were treated with PU alone as the control group,of which 65 cases were H.pylori infection and 25 cases had UGIB.Compare humoral and cellular immune function indicators,bleeding rate,and H.pylori detection rate between the two groups;compare UGIB patients' immune function indicators,blood loss stratification upon admission,hemostatic effect,and length of hospitalization;compare immunity of H.pylori infected patients functional indicators;comparison of immune function indicators of patients with different blood pressure control and EHT course;comparison of immune function indicators of patients with different blood pressure control in different EHT course group.Results: The levels of CD3,CD4,CD8 and CD56 in the study group were lower than those in the control group,and the levels of C3 and C4 were higher than those in the control group(P<0.05);UGIB in the study group accounted for 33.6%,and H.pylori infection accounted for 50.9%.UGIB in the group accounted for 21.4%,and H.pylori infection accounted for 55.6%.The incidence of UGIB in the study group was higher than that in the control group(P<0.05).There was no significant difference in the detection rate of H.pylori between the two groups(P>0.05).The levels of CD3,CD4 and CD8 in H.pylori-infected patients in the group were lower than those in the control group,and the levels of Ig A,Ig E,C3 and C4 were higher than those in the control group(P<0.05).The levels of CD3 and CD4 in the UGIB group in the study group were lower than those in the control group(P<0.05);The stratified blood loss stratification of UGIB patients in the study group was not different from that in the control group(P>0.05),but the effective rate of hemostasis was lower,the inefficiency was higher,and the length of hospital stay was longer(P<0.05);The levels of CD3 and CD56 in patients with poor blood pressure control in the combined EHT group were lower than those in the well-controlled group(P<0.05);in the group with less than 10 years of EHT disease,the level of CD3 in the patients with poor blood pressure control was lower than those in the well-controlled group,and the levels of CD19,Ig A,C3 and C4 were lower.Compared with the increase(P<0.05);CD19 levels in patients with EHT over 10 years were lower than those under 10 years,Ig A and C4 levels were increased(P<0.05),and differences in blood pressure control had no effect on immune function indicators(P>0.05).Conclusion: PU patients with EHT,the immune function is unbalanced and UGIB is easy to be happened,which affects the curative effect.EHT combination had nothing to do with H.Pylori infection rate,but the immune function of infected patients was unbalanced.Early intervention with EHT will help improve outcomes for patients with complications. |
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