Research On Analysis Method Of Brain Cognitive Function Based On Brain Tractographic Atlas

Fiber tracking technology based on diffusion magnetic resonance imaging(d MRI)is a currently important method for non-invasively studying the structure and cognitive function of white matter in the brain.In practical applications,the voxel-based analysis method(VBA)is commonly used to analyze the characteristics of white matter fibers in the brain.However,this method has the following problems:(1)it is very dependent on artificial experience when selecting the region of interest,(2)the mean value is generated when calculating the feature attributes,and the global diffusion information cannot be fully displayed,(3)there is no detailed anatomy annotation,which relies on expert neuroanatomical knowledge to subdivide and annotate fiber bundles.In order to solve these problems,this paper builds an anatomical brain map based on an automatic annotation fiber clustering(AAFC)to analyze the cognitive function of the brain,and targets the two types of cognition of chess players and Alzheimer’s patients.Functionally significant populations were analyzed.The main work of the thesis is as follows:1.Based on the brain atlas,this paper used a data-driven algorithm to divide whole brain fibers into multiple anatomically defined clusters,and studies the cognitive function of the brain at the level of segmentation of clusters(such as the upper longitudinal bundle).First,the second-order Kalman filter fiber tracking method was used to reconstruct whole brain fibers to obtain 150,000 fibers.Second,the whole brain fibers were divided into 800 clusters,and 64 clusters were selected as the region of interest.Finally,each fiber was resampled to 200 equidistant nodes along the entire fiber bundle to calculate the diffusion properties and detect local differences,such as T test and Pearson correlation analysis.Compared with the traditional method,the method in this paper accurately locates the whole brain fiber bundle at a finer scale,and uses multi-point sampling to analyze specific fibers.2.This paper used AAFC method to analyze and study several fiber bundles related to cognitive function in the brains of professional chess players(n = 29)and control group(n = 28).The experimental results confirmed that the white matter of professional chess players’ brains did change in anatomy.Compared with ordinarysamples,almost every fiber bundle has continuous significant differences in fibers,and the diffusion index has an upward trend.The results of Pearson correlation analysis show that this difference has nothing to do with interference factors such as age and gender,and is closely related to the clinical indicators of professional chess players.The experiment also continued to make multiple corrections to verify,strengthened the reliability of the conclusion,and confirmed that chess has an anatomically significant change in human brain white matter cognitive function.3.This paper used a data-driven brain atlas clustering method to refine the brain region fibers,further study the human anatomical indicators,and detect the white matter of Alzheimer’s patients(n = 29)and control groups(n = 28)Anatomical changes related to cognitive deficits.Contrast and analyze the diffusion properties one by one with the regions with significant differences in the previous experiment.The experimental results showed that significant differences in the upper longitudinal bundle and thalamus of Alzheimer’s patients were detected,and the significant points were continuous.This is in accordance with the experimental results in Chapter 3,reducing the scope of research on the cognitive function of human brain and white matter,and proving that both cognitive activities and diseases can affect changes in the human brain anatomy.In this paper,the AAFC method was used to analyze the cognitive function of human brain white matter.The significant difference of professional chess players proves that the anatomy level of the human brain is affected by the cognitive function of the brain.On the other hand,studies on Alzheimer’s patients with cognitive deficits are conducted to support the above views.In summary,the results confirmed that the cognitive function of professional chess players and Alzheimer’s patients can affect the differences in brain anatomy and diffusion properties.White matter fiber characteristics related to memory,attention,and vision may all be affected by long-term cognitive activity.It is of great significance to study the changes of cognitive function mechanism to improve high-level cognitive ability.At the same time,studying the properties of local differences in the brain provides new ideas for studying the development of white matter.