Effect Of Humectants (Curecode Double Barrier Cream) On The Epidermal Permeability Barrier Function Of The Elderly

Objective: To evaluate the effect of humectants(Cure Code Double Barrier Cream)on the epidermal permeability barrier function in the elderly people.Methods: 30 old people over 70 years old were recruited,male and female,with no primary skin diseases in both lower limbs(can have dryness and itching).The left and right tibia were alternately divided into Cure Code Double Barrier Cream treatment group and control group.Cure Code Double Barrier Cream was applied once a day in the morning and in the afternoon for 4 consecutive weeks.The self-control method was used to compare the epidermal barrier function(stratum corneum hydration,transepidermal water loss,p H,and speed of barrier function recovery)of the two groups after test 0,2,4.Results: The experimental study enrolled 30 elderly subjects over the age of 70.The all 30 subjects completed the 2-week test,13 subjects completed the 4-week test,and 17 subjects completed only the test 0 and the test 2 due to the outbreak of the new crown virus in China.1.30 subjects completed 2 weeks of testing,and after statistical analysis:(1)Before the test,there was no statistically significant difference in SCH,TEWL,p H,and the speed of barrier function recovery(P>0.05).(2)During the test period,the SCH of the test group increased,and the difference was statistically significant compared with the control group(P<0.05).(3)During the test period,the TEWL in the test group decreased,and the difference was statistically significant compared with the control group(P<0.05).(4)During the test,the p H of the test group decreased,and the difference was statistically significant compared with the control group(P<0.05).(5)During the test period,the skin barrier recovery rate in the test group decreased,and the difference was statistically significant compared with the control group(P<0.05).2.13 subjects completed 4 weeks of testing,and after statistical analysis:(1)Before statistical analysis there were no significant differences in the SCH,TEWL,the p H,and barrier function recovery rate between the two groups(P>0.05).(2)During the test,the SCH in the test group gradually increased,and the difference was statistically significant compared with the control group(P<0.05).(3)During the test period,the TEWL in the test group gradually decreased,and the difference was statistically significant compared with the control group(P<0.05).(4)During the test,the p H of the test group gradually decreased,and the difference was statistically significant compared with the control group(P<0.05).(5)During the test,the skin barrier recovery rate in the test group decreased,and there was no significant difference compared with the control group.Conclusions: The test results show that after treatment with humectants,the SCH of the treated side increased on the 14 th and 28 th days compared with the control side.The use of humectants(Cure Code Double Barrier Cream)can improve the SCH of the epidermis of the elderly,reduce the p H of the epidermis,repair the damaged skin barrier,and improve the dry skin of the elderly.