PLAC8 Affects Breast Cancer Progerssion By Activating The PI3k/AKT Pathway

The cysteine-rich lysosomal protein placenta-specific 8(PLAC8),has been shown to be involved in many types of diseases,and its role is highly dependent on cellular and physiological contexts.However,the precise function of PLAC8 in breast cancer(BC)progression remains unclear.In this study,we investigated both the clinical significance and biological functions of PLAC8 in BC progression.First,high PLAC8 expression was observed in 55 primary BC tissues compared with adjacent normal tissues through immunohistochemistry analysis and RT-PCR.The results of in vitro and in vivo assays further confirmed that PLAC8 overexpression promotes cell proliferation and suppress BC cell apoptosis,whereas PLAC8 silencing has the opposite effect.Further mechanistic analysis confirmed that PLAC8 contributes to cell proliferation and suppresses cell apoptosis in BC by activating the PI3K/AKT/NF-?B pathway.The results of our study provide new insights into an oncogenic role of PLAC8 and reveal a novel PLAC8/PI3 K pathway as a potential therapeutic target for BC.