The Relationship Between Interleukin-10 Promoter Region(1082A/G) And Early-onset Preeclampsia

Objective:Study the relationship between IL-10-1082?A/G?gene polymorphism and early-onset preeclampsia.Methods:Using case-control study,the experimental group selection in November 2017-November 2019 maternity and child health care in the Inner Mongolia autonomous region by inputting prenatal of 60 patients with early-onset preeclampsia?divided into mild early-onset preeclampsia,severe early-onset preeclampsia each 30 cases?and control group for the same period in our hospital by inputting the gestation 20?33⁺⁶weeks between the 60 cases of healthy pregnant women,to return the peripheral venous blood 3 ml,use Axy Prep-96 blood genomic DNA kit for experimental genomic DNA,PCR-RFLP assay was used to detect the IL-10-1082?A/G?gene polymorphism.The correlation between IL-10-1082?A/G?gene polymorphism and early-onset preeclampsia was analyzed using medical statistical methods.All data were statistically analyzed using SPSS20.0.Results:?1?there were no statistically significant differences in age,height,pre-pregnancy weight,body mass index,weeks of gestation and times of gestation between the mild and severe preeclampsia groups and the normal control groups?P>0.05?.?2?each type of IL-10-1082?A/G?conforms to the Hardy-Weinberg genetic equilibrium law?P>0.05?,indicating that the selected subjects are representative of the population.?3?in the mild and severe early-onset preeclampsia group and the normal control group,the distribution of allele frequencies and genotypes at the IL-10-1082?A/G?locus were different,and the difference between the normal control group and the mild and severe early-onset preeclampsia group was statistically significant?P<0.05?.There was no significant difference between the mild early-onset preeclampsia group and the severe early-onset preeclampsia group?P>0.05?.?4?logistic regression analysis showed that AA genotype in il-10-1082?A/G?increased the risk of early-onset preeclampsia compared with GG genotype,with an OR value?95%confidence interval?of 4.072?1.680-9.868?.Compared with the G allele,the A allele of IL-10-1082A/G also increased the risk of early-onset preeclampsia,with an OR?95%confidence interval?of 2.448?1.499-3.997?.Conclusions:?1?there was no significant correlation between IL-10-1082?A/G?gene polymorphism and the severity of early-onset preeclampsia.?2?There was A significant correlation between IL-10-1082?A/G?gene polymorphism and the risk of early-onset preeclampsia,and the AA genotype was more prone to early-onset preeclampsia than the GG genotype,and the A allele was more closely associated with the early-onset preeclampsia than the G allele.