| Objective: This paper aims to compare the efficacy and safety of the recombinant human endostatin combined with chemotherapy in patients with the squamous cell lung cancer.Methods: Computers searching Cochrane library,Pubmed,Embase,CNKI,Wanfang database,Metstr,VIP and so on for literature search and manual searching of books or magzines till 2019,searching articles about the efficacy and safety of the recombinant human endostatin combined with chemotherapy in patients with the squamous cell lung cancer.And conduct a second search on the review literature.According to the criteria of literature screening,the relevant randomized controlled trials and non-randomized controlled trials of recombinant human endostatin combined with chemotherapy and chemotherapy alone in the treatment of squamous cell lung cancer were included.Two researchers independently evaluated the quality of the study according to the corresponding evaluation criteria.After the data was extracted and analyzed,Revman 5.3 software was used for meta-analysis for the outcome indicator.Then carry out heterogeneity test and sensitivity analysis,test the publish bias of this study by Stata 13.0 software.Results: After browsing 828 articles,6 randomized controlled trials(RCTs)and 8 non-randomized controlled trials(non-RCTs)were included.821 patients with squamous cell lung cancer were summed up.The response rate(RR)is 2.12(95%CI: 1.57-2.85,and P<0.00001).The disease control rate(DCR)is 2.38(95%CI: 1.70-3.32,and P<0.00001).The difference was statistically significant between the two groups.When it came to security,the incidence rates of the adverse reactions such as cardiotoxicity,leukopenia,thrombocytopenia and gastrointestinal reactions were not significantly different between the two groups(OR=1.70,95%CI:0.79-3.68;OR=0.93,95%CI:0.61-1.42;OR=1.08,95%CI:0.71-1.64;OR=0.86,95%CI:0.56-1.30 respectively).Conclusion: The therapeutic efficacy of the combined group was better than that of the chemotherapy group alone.And it did not increase the incidence of adverse reactions such as cardiotoxicity,leukopenia,thrombocytopenia and gastrointestinal reactions in the course of treatment,so it had a high safety. |
