Multivariate Clinical Analysis Of Local Complications In The Later Period Of Severe Acute Pancreatitis

ObjectiveTo study the clinical characteristics of severe acute pancreatitis(SAP),and to analyze the risk factors of complications in the later period of severe acute pancreatitis.MethodsA retrospective analysis was performed on 376 cases of severe acute pancreatitis admitted to the First Affiliated Hospital of Chongqing Medical University from January 1,2015 to June 1,2019.Finally,48 cases of severe acute pancreatitis with local complications at the later period were screened acute pancreatitis with local complications(LC-SAP)and 86 cases of severe acute pancreatitis with non-local complications(NLC-SAP).The basic information of these cases was collected,and the risk factors of late complications in the LC-SAP group and NLC-SAP group were analyzed.ResultsThe age,C-reactive protein,blood urea nitrogen,modified computedtomography severity index(MCTSI)and gastrointestinal dysfunction time(GIDT)of patients in LC-SAP group were higher than those in NLC-SAP group.(P(27)0.05),while the blood calcium and renal replacement therapy rate(RRTR)in the LC-SAP group were lower than those in the NLC-SAP group(P(27)0.05).The results show that in patients with SAP,serum calcium(OR=0.028,P=0.005,95% CI:0.002–0.348)is an independent protective factor for late complications in patients with severe acute pancreatitis,while a higher MCTSI(OR=3.991,P<0.001,95% CI:2.143–7.436)and time to gastrointestinal dysfunction(OR=1.247,P=0.045,95%CI:1.045–1.547)were independent risk factors for local complications.ConclusionHypocalcemia,higher MCTSI,and longer GIDT increase the risk of local complications in the later period of SAP.