The Expression Level Of PPAR? In Subcutaneous Adipose Tissue Of Overweight And Obese Pregnant Women With Gestational Diabetes

Objective: To study the expression level of PPAR? in subcutaneous adipose tissue of overweight and obese pregnant women with gestational diabetes mellitus.Methods: in this study,70 cases of gestational diabetes and 70 healthy pregnant women in the same period from January 2015 to April 2017 were selected as subjects.According to the results of 75 g impaired glucose in the second trimester,they were divided into diabetic group(G group)and normal group(N group),and then according to the BMI level of the two groups of pregnant women,they were GDM/normal BMI group(G1 group),GDM/high BMI.Group(G2 group);normal blood glucose/normal BMI group(N1 group),normal blood glucose/high BMI group(N2 group).Comparative analysis of general data of four groups of pregnant women,pre-pregnancy BMI,pre-delivery BMI,fasting plasma glucose(FPG),fasting insulin level(FINS),insulin resistance(HOMA-IR),adiponectin(APN)At the same time,the expression level of PPAR? m RNA in abdominal subcutaneous adipose tissue of four groups of pregnant women was quantitatively analyzed by immune histochemical semi-quantitative protein expression and RT-PCR.Results: The FINS and HOMA-IR of patients with gestational diabetes mellitus with high BMI index were significantly higher than those of normal pregnant women and those with normal BMI index,while APN were significantly lower(P<0.05).The semi-quantitative PPAR? group was significantly higher than that of normal pregnant women;the PPAR? m RNA of gestational diabetes mellitus with high BMI index was significantly higher than that of normal pregnant women and gestational diabetespatients with normal BMI index(P<0.05).Conclusion: The expression of PPAR? is increased in the abdominal subcutaneous adipose of pregnant women with gestational diabetes.The increase of obese pregnant women is more obvious.PPAR?and obesity are associated with the occurrence of gestational diabetes.