The Distribution Of TCM Syndromes In IVF-ET Before Embryo Transplantation Period And The Correlation Analysis With Endometrial Thickness And Clinical Pregnancy Rate

ObjectiveTo research the Traditional Chinese Medicine syndromes?endometrial thickness and pregnancy rate of patients who take IVF-ET before embryo transplantation,then investigate the distribution of Traditional Chinese Medicine syndromes in IVF-ET and the relationship between syndromes and endometrial thickness,analyse the pregnancy rate as well as the related influence factors.Set the foundation for Objectification and Standardization of Chinese medicine prescription and medication in IVF-ET that before embryo transplantation.MethodsInfertile patients who undergoing the IVF-ET were came from the Reproductive Women and Children's Hospitl Affiliated To Chengdu University of Traditional Chinese Medicine and the Reproductive Center of Sichuan Provincial People's Hospital from October 2018 to December 2019.Using clinical epidemiological investigation method and all of the patients were treated with standard long protocol to down-regulated and controlled ovarian hyper-stimulation that belonged to before embryo transplantation period.At the same time,collecting the general condition questionnaire and syndrome questionnaire.Using SPSS21 to analyze the distribution of each syndrome type,as well as the correlation between syndrome type and age,educational background,previous pregnancy history,abortion history and the distribution of syndrome type,and the correlation between syndrome type and endometrial thickness,and the final pregnancy outcome.Results1?Before embryo transplantation period,311 patients(55.6%)with TCM syndrome type that the rate of deficiency syndrome were more than excess syndrome(44.4%).In the specific syndrome type,kidney yang deficiency syndrome is the most common(25.7%),then liver stagnation syndrome(21.2%)?kidney deficiency syndrome(19.6%)?phlegm and dampness block syndrome(16.1%)?kidney yin deficiency syndrome(10.3%)?blood stasis block(7.1%)2?Before embryo transplantation period,IVF-ET patients had different syndrome types in terms of the number of abortions(P<0.05),there was no difference in age?educational background?disease course and etiology(P>0.05).3?The pregnancy rate of 311 patients was 44.1%,and the pregnancy rate of different syndrome types was significantly different(P<0.05).The pregnancy rate of patients with liver stagnation syndrome was the highest(59.1%),patients with blood stasis block was the lowest(27.3%).The pregnancy rate of patients with 8-12 mm Before embryo transplantation period was higher than patients with endometrial ?7mm and?13mm(P<0.05).Conclusion1?Before embryo transplantation period,kidney yang deficiency syndrome is the most common,then liver stagnation syndrome?kidney deficiency syndrome?phlegm and dampness block syndrome?kidney yin deficiency syndrome?blood stasis block.2?Before embryo transplantation period,The patient with TCM syndrome type of greater than 35-year-old was mainly liver stagnation syndrome;the higher the number of abortions,the greater the possibility of kidney yang deficiency syndrome,and there may be a correlation between TCM syndrome type and the number of abortions.3?Before embryo transplantation period,The thin endometrium was dominated by kidney Yin deficiency,while the thick endometrium was dominated by blood stasis block.The pregnancy rate of patients with different syndrome types is different that IVF-ET patients with a film thickness of 8-12 mm had a relatively higher pregnancy rate.