Study On The Correlation Between Brain Metastatic Syndrome Type And Prognostic Factors In Lung Cancer

Research purposes: By retrospectively analyze clinical data in patients with brain metastases from lung cancer,the study of TCM syndrome types of patients with brain metastases from lung cancer with gender,age,tumor infiltration depth,regional lymph nodes,pathological type,the number of brain metastasis,place and time,maximum diameter,symptoms,treatment,KPS score,lung cancer radical prostatectomy,targeted therapy,the control condition from the primary lesion and amount transfer factors such as the intrinsic correlation,the application of traditional Chinese medicine to predict the prognosis of lung cancer with brain metastasis,provide objective basis for syndrome differentiation and treatment of brain metastases from lung cancer,and early active adoption of traditional Chinese medicine to improve the prognosis of patients with brain metastases from lung cancer.Methods: a total of 111 patients in the inpatient department of oncology department of sichuan hospital of traditional Chinese medicine from January 2015 to January2020 were collected,and an observation table was designed to analyze the correlation between TCM syndrome differentiation and prognostic factors of the included patients.SPSS19.0 statistical analysis software method was used for chi-square test,and the sample size was small in some cases.Fisher’s exact probability method was used.P<0.05 was considered statistically significant.Moreover,P<0.0 was still considered statistically significant by multiple comparisons between syndromes.Results: 1.The distribution of TCM syndromes in patients with brain metastasis of lung cancer was 43.2%.The second is phlegm-turbidity syndrome,liver-kidney Yin deficiency syndrome,liver-wind internal motion syndrome,qi and blood stasis syndrome,accounting for 21.6%,14.4%,11.7% and 9% respectively.The ratio of men to women is 1.4:1.Except for qi and blood stasis type,there were more male patients among the other syndromes,and there were significant differences between liver wind internal motion syndrome and qi and blood stasis syndrome(P<0.05).2.The maximum diameter of brain metastasis of lung cancer was 1.5-3cm in frequency;Phlegm-stasis and heat accumulation syndrome,phlegm-turbid-excess syndrome,and intrahepatic wind movement syndrome were mostly seen with the diameter of 1.5-3cm.The proportion of liver and kidney Yin deficiency syndrome in diameter <1.5cm was the highest.The ratio of liver wind internal motion syndromeand blood stasis was the highest with the diameter of >3cm.There was statistical significance between liver and kidney Yin deficiency syndrome and liver wind internal motion syndrome(P<0.05).3.Brain transfer time <6 months accounted for the highest proportion in frequency,accounting for 57.7% of the total;Phlegm stasis and heat accumulation syndrome,good phlegm obstruction syndrome and liver and kidney Yin deficiency syndrome were more common than 6 months.Liver wind internal motion to > more than 12months;Qi and blood stasis syndrome with > more than 12 months.There was statistical significance between excessive phlegm and intrahepatic wind movement(P<0.05).4.The supratentorial location of brain metastasis was the highest in frequency and subtypes,accounting for 55.0% of the total;Phlegm stasis and heat were mostly seen in the supratentorial area(frontal parietal occipital lobe).Excessive obstruction of sputum turbidity was common in the upper or upper and lower curtains(frontal occipital lobe,cerebellum).The syndrome of liver and kidney Yin deficiency was mostly seen in the upper screen(frontal lobe,parietal lobe).The liver wind moves the syndrome to be seen more often with the curtain,next is the prefrontal occipital lobe and cerebellum on the curtain and the curtain);Qi and blood stasis were mostly seen on the screen(cerebellum).There was statistical significance between excessive phlegm-turbidness and liver and kidney Yin deficiency(P<0.05).5.In the distribution of TCM syndromes with or without radical resection of lung cancer,there was statistical significance between excessive phlegm and intrahepatic wind movement(P<0.05).6.In the distribution of TCM syndromes with or without clinical symptoms,there was statistical significance between excessive phlegm and deficiency of liver and kidney Yin(P<0.05).7.The phlegm-stasis and heat accumulation syndrome were statistically significant with phlegm-turbid-excess syndrome(P<0.05),phlegm-excess syndrome was statistically significant with liver-kidney Yin deficiency syndrome(P<0.05),and liver-kidney Yin deficiency syndrome was statistically significant with intrahepatic wind movement syndrome(P<0.05).There was no significant difference in age,tumor invasion depth,regional lymph node metastasis,pathological type,treatmentmode,primary lesion control,targeted therapy,KPS score,multiple metastasis and TCM syndrome type(P>0.05).Conclusion: 1.111 patients with brain metastasis of lung cancer had the most phlegm stasis and heat syndrome(48 cases,43.2%).Secondly,there were 24 cases with excessive phlegm,accounting for 21.6%.Liver and kidney Yin deficiency syndrome,16 cases(14.4%);There were 13 cases of liver wind internal motion syndrome,accounting for 11.7%.Qi and blood stasis syndrome was the least(9 cases,9%).The number of cases with phlegm-stasis and heat accumulation and phlegm-turbidity excess is more than half,which indicates that the pathological factors of brain metastasis of lung cancer mainly lie in blood stasis and phlegm turbidity.2.There was no significant correlation between age,tumor invasion depth,regional lymph node metastasis,pathological type,treatment method,primary lesion control,targeted therapy,KPS score,multiple metastasis and TCM syndrome type.Gender,number of brain metastases,time of brain metastases,location of brain metastases,maximum diameter of brain metastases,radical resection of primary lesions,and clinical symptoms or not were included in the TCM syndrome differentiation of brain metastases in lung cancer(P<0.05).The prognosis of dampnessheat stasis syndrome a nd phlegm-dampness block was relatively poorfollowed by liver wind internal motion syndrome,and the prognosis of qi and blood stasis syndrome and liver and kidney Yi n deficiency syndrome was relatively good.