| Objectives This study intends to use the Ba Duan Jin Gong method to intervene in patients with pre-diabetes,and to observe the improvement of clinical indicators such as intestinal flora,insulin resistance index,blood sugar and blood lipids in pre-diabetes patients after regularly practicing Ba Duan Jin.The clinical significance of Baduanjin in slowing or preventing the transition from prediabetes to type 2 diabetes and improving the quality of life of prediabetes patients.Methods 80 patients who meet the diagnostic criteria of prediabetes mellitus were recruited from 3 community hospitals in the city of Chengdu in this study.80 patients were randomly divided into experimental group and control group,40 in each group.Routine health education was used in the control group,experimental group added the Baduanjin intervention on this basis.According to the living address of the patients and their own wishes,5-10 people were divided into a group.Each group elects a team leader who is responsible for roll call people and supervision of every once exercise.At least once a week the professional Baduanjin teacher went to the scene to teach the keypoints of Baduanjin actions.Together exercise at least 3 times a week,and the rest time practiced at home and used We Chat group to sign in.Observe the changes of the patient's intestinal flora,Insulin resistance index,blood glucose,blood lipid,BMI and other indicators in the finally.And statistical software SPSS19.0 was used for statistical analysis of all data.Objectively evaluate the value of health Qigong·Baduanjin in improvement of blood glucose control and quality of life of prediabetes mellitus patients.Results 1.Baseline data: There was no statistically significant difference in general datasuch as gender,age,education,marital status,occupational category,and mont hly family income between the two groups of subjects(P> 0.05).There was n o statistical difference in the comparison of indicators(P> 0.05),and they wer e comparable at baseline.2.Intestinal flora: There was no statistically significant difference between the t wo groups of patients before the intervention between the Firmicutes,Bacteroide tes,Proteobacteria,and Actinobacteria(P > 0.05),after 6 months of intervention,the relative abundance of Firmicutes and Proteobacteria decreased in both gro ups;the relative abundance of Bacteroidetes and Actinobacteria in both groups increased,and there is statistically significance of the difference between the t wo groups(P < 0.05).The ratio of Bacteroidetes /Firmicutes(B / F ratio)befor e and after treatment in the control group and the test group were 0.37,0.38,0.36,and 0.57,respectively.The difference in B / F value between the two gr oups after treatment was statistically significant(P <0.05).From the perspective of class,the relative abundance of Clostiadia in both groups decreased,the relative abundance of Bacilli increased by 1.67%,and t he experimental group decreased by 3.52%;the relative abundance of Bacteroid ia increased in both groups.The difference was statistically significant(P <0.05).From the perspective of genus,the abundance of Bacteroides and Bifidobact erium in both groups increased,while the abundance of Escherichia and Rumin ococcus decreased,and there is statistically significance of the difference betwe en the two groups(P <0.01).Lactobacillus and Clostridium increased,but there is no statistically significance of the difference between the two groups(P> 0.05).3.Insulin resistance index: After 3 months of intervention,there was no statistic ally significance between the two groups in the insulin resistance index(P> 0.05),after 6 months of intervention,there was a statistically significance in the t wo groups of insulin resistance index(P <0.05)Repeated analysis of variance analysis showed that the insulin resistance index was statistically different between the effects of groups,time effects and interaction effects(P <0.05).4.Blood glucose: The difference in fasting blood glucose and blood glucose at 2 hours after meal between the 3 months and 6 months of intervention was st atistically significant(P <0.05).Repeated measurement analysis of variance sho wed that fasting blood glucose and 2 hours after meal The hourly blood gluco se was statistically different in the effects among groups,time effects and inter action effects(P <0.05).5.Blood lipids: There was a statistically significant difference in TC,TG,and L DL-C between the two groups of patients after 3 months of intervention(P <0.05),while there was no statistically significant difference in HDL-C(P> 0.05).After 6 months of intervention the TC,TG,HDL-C,and LDL-C were signifi cantly different(P <0.05).Repeated measurement of variance results show that TC,t TG,and LDL-C There were statistical differences in group effects,time effects,and interaction effects(P <0.05).There was no statistically significant difference in HDL-C effect between groups(P> 0.05),and there were statistica lly significant differences in time effect and interaction effect(P <0.05).6.Body weight and body mass index: There was a statistically significant differ ence in body weight between the two groups of patients after 3 months of int ervention(P <0.05).There was no statistically significant difference in body m ass index(P> 0.05).The differences in body mass index were statistically sign ificant(P <0.05),and repeated analysis of variance showed that body weight h ad statistical differences in group effects,time effects,and interaction effects(P <0.05).There was no statistically significant difference in body mass index between group effects(P> 0.05),and there were statistically significant differen ces in time effects and interaction effects(P <0.05).7.Waist-to-hip ratio: There was a statistically significant difference in waist-to-h ip ratio between the two groups after 3 months and 6 months of intervention(P <0.05).Repeated analysis of variance analysis showed that the waist-to-hip ratio had an effect between groups and time And there were statistical differe nces in interaction effects(P <0.05).8.Hamilton anxiety score and Pittsburgh Sleep Quality Index score: There was a statistically significant difference in the Hamilton anxiety score and Pittsburg h Sleep Quality Index score between the two groups of patients at 3 months a nd 6 months after intervention(P <0.05).Repeated analysis of variance analysi s showed that the Hamilton anxiety score and Pittsburgh Sleep Quality Index s core had an effect between groups and time.And there were statistical differen ces in interaction effects(P <0.05).Conclusion 1.Persist in Baduanjin exercise can increase the number of Bacteroides phylum,reduce the number of Firmicutes phylum,and adjust the intestinal B / F ratio.At the same time,the increase in the number of beneficial bacteria can regulate the obesity status and IR status of patients,which in turn affects the evolution of PDM patients to T2 DM,and ultimately serves to delay or prevent the occurrence of T2 DM.2.Baduanjin exercise can reduce fasting blood glucose,blood glucose level 2 hours after a meal and higher blood lipid levels in PDM patients.3.Long-term Baduanjin exercise can promote gastrointestinal motility of the human body,reduce fat accumulation,and then play a role in reducing body weight and regulating BMI.4.Adhering to the exercise of Ba Duan Jin can relieve liver and qi,stabilize emotions,reduce the anxiety level of PDM patients,and improve the sleep quality of patients. |
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