The Pathogenesis Of Meniere's Disease Impacted By Hormones Adjusting Water-salt Metabolish

Objective To investigate the role of salt and water metabolism hormones in the pathogenesis of Meniere's disease by comparing the levels of antidiuretic hormone(ADH),aldosterone(ALD)and glucocorticoid(GC)in peripheral blood of the patients with Meniere's disease and the control group,and investigate the role of metabolic hormone of water and salt in the pathogenesis of MD.Methods 47 patients diagnosed as MD in the otolaryngology outpaitent and inpatients of our hospital from May 2019 to December 2019 were selected as the experimental group;healthy volunteers aged 18-67 years without history of ear and nose diseases during the same period,19 outpatients and inpatients from the otolaryngology department were selected as the control group.In the experimental group,blood samples were collected within 48 hours of the onset of vertigo,and 5 mL of fasting blood was collected 4 weeks after the last episode of remission,and 5 mL of fasting blood was collected in the control group,and the serum was centrifuged at 3600 r/min for 10 minutes storted in-80 ? refrigerator to be tested.The levels of ADH,ALD and GC in serum were detected by enzyme-linked immunosorbent assay.Both were given special physical examination,pure tone audiometry,acoustic impedance,cochlear electrogram,otoacoustic emission,auditory brainstem response,and caloric test.All data are saved with Excel,and analysied with SPSS24.0.Statistical methods include descriptive analysis,t test,chi-square test,analysis of variance,Mann-Whitney U test.Results 1.Comparison between groups:1)Comparison between the experimental group and the control group: the ADH content in the serum of the experimental group was 23.98±7.44 ?g/ml,the control group was 19.83±6.71 ?g/ml,the difference was statistically significant(P <0.05);the ALD content of the experimental group was 112.57(93.16,143.23)?g/ml,the control group was 98.40(82.00,108.61)?g/ml,the difference was statistically significant(P <0.05);the experimental group GC content was 0.74(0.38,1.67)?g/ml,the control group was 0.88(0.32,1.65)?g/ml,the difference was not statistically significant(P>0.05).2)Comparison between the onset period of the experimental group and the control group: the ADH concentrations in the acute attack period of the experimental group and the control group were 24.93±7.44 ?g/ml and 19.83±6.71 ?g/ml respectively,the difference was statistically significant(P <0.05);The ALD concentrations of the acute attack period of the experimental group and the control group were 115.82(95.37,142.78)?g/ml and 98.40(82.00,108.61)?g/ml respectively,the difference was statistically significant(P<0.05);The GC concentrations of the acute attack period of the experimental group and the control group were 0.62(0.37,1.52)?g/ml and 0.88(0.32,1.65)?g/ml,the difference no statistical significance(P>0.05).3)Comparison between the intermittent period of the experimental group and the control group: the ADH concentrations of the intermittent period of the experimental group and the control group were 20.85±6.87 ?g/ml and 19.83±6.71 ?g/ml,respectively,the difference was not statistically significant(P>0.05);The ALD concentrations ofthe intermittent period of the experimental group and the control group were 104.80(81.37,157.17)?g/ml and 98.40(82.00,108.61)?g/ml,respectively,with no statistically significant difference(P>0.05);the GC concentrations of the intermittent period of the experimental group and the control group were 0.88(0.72,8.62)?g/ml and 0.88(0.32,1.65)?g/ml,respectively,the difference no statistical significance(P>0.05);2.Comparison within the group: The ADH concentrations the acute attack period of the experimental group and intermittent period of the experimental group were 24.93±7.44 ?g/ml and 20.86±6.87 ?g/ml,respectively,the difference was not statistically significant(P>0.05);The ALD concentrations in the acute attack period of the experimental group and intermittent period of the experimental group were 122.82±42.08 ?g/ml and 116.49 ±37.74 ?g/ml,the difference was not statistically significant(P>0.05);the GC concentrations in the acute attack period of the experimental group and intermittent periods of the experimental group were 0.62(0.37,1.52)?g/ml and 0.88(0.72,8.62)?g/ml,respectively,the difference statistically significant(P<0.05)Conclusions 1 The abnormal levels of ADH and ALD in peripheral blood of MD patients may be related to the formation of hydrops in the inner ear membrane.2 The GC of peripheral blood of MD patients participates in the maintenance of lymphatic homeostasis in the inner ear membrane labyrinth,which helps to alleviate the water accumulation in the inner ear membrane labyrinth.Figure [0];Table [9];Reference [85]...