| Objectives To explore the impact of maternal pregnancy stress exposure and earthquake pregnancy exposure at different pregnancy stages on the outcome of schizophrenia.Methods 1 Meta-analysis was started with screening cohort studies of stress events experienced by mothers during pregnancy.The search time was set from database construction to May 2019.The information was extracted by two people and the quality of the literature was evaluated twice.Rev Man5.3 and State15.0 was used for statistical analysis.Followed with qualitative,sensitive and publication bias analysis.2 By method of a retrospective cohort study design,the selected subjects were divided into an exposure group and a control group according to whether the mother experienced Tang Shan earthquake exposure during pregnancy.In the exposed group,they were divided into different subgroups according to the mother's pregnancy period.The incidence of mental disorders in each cohort calculate and then compared.Results 1 Meta-analysis included 13 cohort studies with a total of 3342829 people,including 536142 in the exposed group and 2806687 in the control group.Stress during maternal pregnancy increased the risk of schizophrenia by 43%[RR=1.43,95%CI(1.17,1.73),P=0.00001 ],heterogeneity test indicates that research is heterogeneous(P<0.00001,I2=91%).According to the subgroup analysis of stress duration,the results showed that the incidence of schizophrenia in offspring of the short-term stress group was higher than that of the control group[RR=1.10,95%CI(1.01,1.20),P=0.03],and the incidence of schizophrenia in offspring of the long-term stress group was higher than that of the control group[RR=1.69,95%CI(1.58,1.80),P<0.00001].There was no significant difference between The stress group that could not determine the duration and the control group.There was a statistically significant difference in the incidence of schizophrenia during early maternal exposure to stress[RR=1.23,95%CI(1.07,1.43),P=0.005 ].There was no statistically significant difference in the incidence of schizophrenia between the second and third trimesters of mothers exposed to stress.Maternal Experience of stress was no statistically significant difference in the incidence of schizophrenia between sexes.2 Retrospective cohort study found that the incidence of schizophrenia in the Tang Shan earthquake population during pregnancy was 10.08‰,RR=1.18(P < 0.05),95%Cl(1.09,1.28),Mortality-adjusted incidence rate of schizophrenia in women who experienced earthquakes during pregnancy was 11.35‰,the mortality-adjusted RR was 1.21,95%Cl(1.12,1.30).The Mortality-adjusted incidence rate of early pregnancy was 11.33‰,mortality-adjusted RR was 1.24(P < 0.05).The mortality-adjusted incidence rate of the second trimester was 12.15‰,the mortalityadjusted RR was 1.31(P < 0.05).The Mortality-adjusted incidence rate of third trimester was 9.58‰,the mortality-adjusted RR was 1.04(P =0.61).In the comparison of gender differences between the stress group and the control group,the incidence risk of offspring males was lower than that of females [OR=0.992(P=0.009)].There was no significant difference in family history of mental illness between the stress group and the control group(P=0.058).Conclusions 1 Meta-analysis showed that increased risk of offspring schizophrenia when exposed to stress during maternal pregnancy;Both long-term and short-term stress may increase the incidence of schizophrenia in offspring;Stress experienced during the first trimester leads to increased incidence of offspring schizophrenia;There was no statistically significant difference in the second and last trimester exposure to short-term adverse life event group and control group.2 The epidemiological investigation showed that the maternal experience of Tang Shan earthquake stress during pregnancy increased the incidence of schizophrenia in offspring;Compared with the control group,the Tang Shan earthquake in the first and second trimester resulted in increased incidence of schizophrenia in the offspring;Maternal experience of earthquake stress during pregnancy has a higher incidence of schizophrenia in female offspring than in male offspring.Figure[11];Table[9];Reference[77]... |
PDF Full Text Request