| Objective: To study the effect of balanced chromosomal translocation and translocation characteristics on the therapeutic effect in controlled ovarian stimulation(COS).Methods: 286 COS cycles of preimplantaion genetic diagnosis(PGD)in our hospital were divided into two groups according to gender.Group A: only the female was the balanced translocation carrier(138cycles),B: only the male was the balanced translocation carrier(148cycles).Then the group A was divided into two subgroups according to different translocation patterns,group A1 was reciprocal translocation and group A2 was Robertson translocation.The ovulation induction and embryo development in COS were compared among groups.Results: The number of retrieved oocytes and the number of normal signal blastocysts in group A were lower than that in group B,but there was no significant difference(P>0.05).The number of 2PN cleavage and the number of normal signal blastocysts in group A1 were significantly lower than that in group A2 in terms of reciprocal translocation and Robertson translocation among female chromosome(P<0.05).Further analysis of the exchange fragments and breakage sites of Robertson translocation of female chromosome showed that the frequency of translocation between chromosome13 and chromosome 14 was the highest,and the q10 region was the region with high occurrence of breakpoint sites.The number of 2PN cleavage and the number of normal signal blastocysts formed by such translocation were higher than other chromosomal translocation(P<0.05).Conclusion:(1)The balanced chromosomal translocation of female does not affect the ovarian response in controlled ovarian stimulation.(2)The possibility of unbalanced embryo formed by reciprocal translocation of female chromosome is higher than that of Robertson translocation.(3)In female chromosome Robertson translocation,different chromosome fragments and their breakage sites have different effects on embryo development. |
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