| ObjectiveTo observe the clinical efficacy and safety of "modified xiao-yao-san" in the treatment of breast cancer after oral administration of Tamoxifen(TAM)to cause endometrial thickening and related TCM syndromes,and take oral tamoxifen for breast cancer patients Provide side effects such as endometrial th ickening and provide effective interventionResearch methodCollecting the disease information of 60 postmenopausal breast cancer patients who were treated in the outpatient department and ward of the Oncology Dep artment of the First Affiliated Hospital of Heilongjiang University of Traditional Ch inese Medicine from December 2018 to December 2019.recepto r all meet the inclusion criteria.Sixty patients were randomly divided into a treatment group and a control group,with 30 patients in each group.The control group received routine treatment of tamoxifen alone with 10 mg oral bid,and regular observation by gynecological ultrasound.On the basis of the control group,the treatment group added "modified xiao-yao-san",150 ml morning and even ing warm service;3 months as a course of treatment,a course of treatment,obs erve the endometrial thickness and traditional Chinese medicine of the two groups Pending points,KPS scores and safety indicators,statistical analysis of the above in dicators,and finally draw conclusions.ResultComparison of general information: the age,pathological type,immun ohistochemistry,oral TAM time,endometrial thickness,TCM syndrome score,and KPS score of the two groups all meet P> 0.05,no significant difference between th e two groups Patients are comparable.Comparison of endometrial thickness:(1)The control group had8.03 ±1.88 before treatmen t and 8.23 ± 1.8 5 after treatment,with no significant difference(P>0.05).(2)The treatment group had8.27 ±1.70 before treatment and 6.87 ±1.81 after treatment,with a significant difference(P<0.01).(3)After treatment,the two groups of patients were tested by independent t test,difference was statistically significant(P<0.0 1).Comparison of TCM syndrome scores:(1)The control group had26.23 ±5.15 before treatment and 26.50 ±5.61 after treatment,with no significant difference(P>0.05).(2)The treatment group had 25.87 ±5.02 before treatmen t and 16.30 ±5.02 after treatment,with a significant difference(P<0.01).(3)After treatment,the independent t test for two groups of patients,difference was statistically significant(P<0.0 1).Comparison of KPS score:(1)The control group had 80.67 ±6.40 before treatment and 79.00 ±8.45 after treatment,with no significant difference(P>0.05).(2)The treatmen t group had 79.33 ±6.91 before treatment and 84.00 ± 8.14 after treatment,with significant differences(P<0.01).(3)After treatment,the independent t test of two groups of patients,difference was statistically significant(P<0.05).Conclusion1.M odified xiao-yao-san can effectively treat endometrial th ickening caused by oral tamoxifen after breast cancer surgery.2.M odified xiao-yao-san of Xiaoyaosan can improve the clinical symptoms of traditio nal Chinese medicine caused by oral tamoxifen,and can improve the quality of life of patients. |
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