Study On The Changes Of Coagulation Indexes In Patients With Crohn's Disease

Background:Crohn's disease(CD)and ulcerative colitis(UC)are two main manifestations of inflammatory bowel disease(IBD).IBD is a chronic recurrent inflammatory disease characterized by local and systemic inflammation,which may affect the whole gastrointestinal tract and colon mucosa.Thromboembolism is an important complication that may be life-threatening in IBD.It plays a role in the venous and arterial system.Deep venous thrombosis and pulmonary thromboembolism are the most common types of thromboembolism in IBD patients.Thromboembolism has a certain morbidity and mortality in IBD patients.The root cause of thrombosis is the imbalance between the prethrombotic state and antithrombotic mechanism Thrombosis is related to three basic mechanisms:blood stasis,endothelial damage or vascular damage and hypercoagulable state.Inflammation stimulates coagulation,damages the fibrinolytic system and reduces the activity of natural anticoagulant mechanism.Meanwhile,natural anticoagulant factors inhibit the increase of cytokines induced by inflammation.The complex interaction between inflammation and coagulation plays a key role in the process of thromboembolism in IBD patientsAims:Based on the IBD population in China,this study further explores the changes of coagulation function in the process of disease,so as to improve the prognosis and quality of life of patients by early detection,early prevention and early treatment.As mentioned in the previous article,the incidence of thromboembolism in CD patients and UC patients is basically the same.Therefore,the purpose of this study is to observe the change of coagulation index in CD patients during the course of disease,explore the role of coagulation function in disease activity,so as to increase the understanding of the process of thromboembolism in CD patients,so as to evaluate the patients through coagulation index in outpatients and inpatients in the future.The risk of thromboembolism should be treated as early as possible.Methods:The clinical data of 53 CD patients and 54 healthy controls diagnosed for the first time from January 2015 to June 2019 were analyzed retrospectively.The differences of DD,fibrinogen,platelet,FDP,Pt and APTT between the two groups were compared to explore the relationship between the changes of these coagulation indexes and CDAI.Result:The fibrinogen,APTT and platelet in CD group were significantly higher than those in normal control group.The blood coagulation indexes of CD patients were compared according to sex,age of diagnosis,defecation,perianal lesion,lesion site and disease behavior.There was no significant difference in DD,fibrinogen,platelet count,FDP,PT and APTT among the groups(P>0.05).According to the classification of Crohn's disease activity index(CDAI),the fibrinogen,PT and FDP of patients in remission stage were significantly lower than those in active stage.Pearson linear correlation analysis showed that CDAI was positively correlated with fibrinogen,PT,FDP and platelet(r=0.326,0.300,0.306,0.271,P<0.05).Conclusions:Compared with the normal controls,the coagulation and fibrinolysis process of CD patients have changed significantly.In this study,there is no significant difference in the coagulation function of CD patients in different gender,age of diagnosis and disease performance.In this study,we found that fibrinogen,FDP,PT and APTT are related to disease activity,while fibrinogen,platelet count,FDP and PT are closely related to CDAI,which can be a predictor of disease activity.