| Background: Kawasaki disease(KD)is an acute,systemic vasculitis and occurs mainly in childhood.Interleukin-6(IL-6)is a pleiotropic cytokine synthesized predominantly by neutrophils and monocytes/macrophages and plays an important role in systemic inflammatory disease.However,a little information is currently available on the relationship of serum IL-6 with conventional inflammatory mediators,clinical classification,IVIG response and coronary artery aneurysm(CAA).Methods: 165 Chinese children with KD were enrolled and divided into 6 subgroups,including complete KD,incomplete KD,IVIG-responsive KD,IVIG-nonresponsive KD,coronary artery noninvolvement KD and coronary artery involvement KD.Blood samples were collected from all subjects within 24 hours pre-and 48 hours post-IVIG therapy,respectively.Serum IL-6 and conventional inflammatory mediators were detected.Results:(1)Serum IL-6 was markedly increased in the acute phase of KD,whereas declined to normal after IVIG therapy;it was positively correlated with C-reactive protein and erythrocyte sedimentation rate.(2)Serum IL-6 was significantly elevated in patients with incomplete KD when compared with their complete counterparts;The area under receiver operating characteristic curve(AUC)value for serum IL-6 in prediction of incomplete KD was 0.596,and the estimated sensitivity and specificity were 77.80% and 54.40% with a cut-off of IL-6 >13.25 pg/ml,respectively.(3)Serum IL-6 was significantly elevated in patients with IVIG-nonresponsive KD when compared with their IVIG-responsive counterparts;the AUC value for serum IL-6 in prediction of IVIG-nonresponsive KD was 0.580,and the estimated sensitivity and specificity were 60.00% and 66.30% with a cut-off of IL-6 >26.40 pg/ml,respectively.(4)No significant differences in IL-6 were found between KD patients with and without CAA.Conclusions: IL-6 is prone to be a candidate biomarker for predicting incomplete and IVIG non-responsive KD rather than CAA. |
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