Expression And Clinical Significance Of IL-26 In Hepatitis B Virus-associated Acute-on-chronic Liver Failure

Objective: To investigate the expression level of Interleukin-26(IL-26)in Hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF)and its clinical significance.Methods: Serum IL-26 levels were measured by enzyme-linked immunosorbent assay(ELISA)in 53 patients with Hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF),53 patients with Chronic hepatitis B(CHB)and 18 healthy controls.General data were statistically analyzed,relevant clinical indicators were analyzed for their correlations with IL-26.Multivariate logistic regression analysis was used to assessed independent risk factors for prognosis of patients.ROC curve and survival curve were used to evaluate the prognosis performance of patients.Results: The level of IL-26 in HBV-ACLF patients was significantly higher than that of non-ACLF patients.The expression of IL-26 was positively correlated with creatinine(CREA)(r = 0.309,P = 0.027)and activated partial thromboplastin time(APTT)(r =0.375,P = 0.006),and inversely correlated with platelet count(r =-0.272,P = 0.049).Multivariate logistic analysis showed that total bilirubin(TBIL)(P = 0.036)and IL-26(P = 0.012)were independent risk factors.The prognostic model established by MELD combined with IL-26(AUC: 0.933,95%CI: 0.829 ? 0.983)was higher than the area under the curve of single IL-26(AUC: 0.846,95%CI: 0.720 ? 0.930)and MELD score(AUC: 0.851,95%CI: 0.727 ? 0.934),it was more sensitive and accurate than that of single index.Serum IL-26>1019.68 pg/ml has reliable prognostic accuracy in predicting90-day mortality in patients with HBV-ACLF.Conclusions: The level of IL-26 is significantly increased in patients with HBV-ACLF,which has important clinical significance and application value in monitoring the condition and prognosis of patients with HBV-ACLF.