The Study On The Status Quo Of Mild Cognitive Impairment Of Older Adults And The Evaluation Of Lifestyle Interventions On Cognitive Function Of Older Adults

Objectives1.Use questionnaire survey which contains Montreal cognitive assessment(MoCA)to investigate both the status of cognitive function and prevalence of mild cognitive impairment(MCI)in the elderly over 65 years old,then analyze the population distribution characteristics by statistical methods.2.Systematic evaluation of the effects of multiple interventions including nutrition and exercise on cognitive function of the elderlyMethods1.From September 2019 to December 2019,the elderly aged 65 and above in the community were selected to investigate the general situation and cognitive function.2.We searched PubMed,EMbase,The Cochrane Library,Web of Science,Science Direct,China National Knowledge Infrastructure,VIP Information and Wanfang DATA E-Resources databases from inception to September 2019 to collect randomized controlled trials(RCTs)on multiple interventions including nutrition and exercise for older adults.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies,meta-analysis was performed by Review Manager v.5.3 software.Publication bias was estimated by Egger's test.Results1.There were 218 older adults who met the include criteria in which 75 older adults were diagnosed with MCI.The prevalence rate was 34.4%.There were statistical differences in the distribution of MCI among age,education,income and regular exercise.The mean scores of older adults with MCI in the seven domains of MOCA were 3.35 ± 1.06,2.96 ± 0.18,2.01 ± 0.81,2.46 ± 0.63,1.70 ± 0.51,4.05 ±0.79 and 5.90 ± 0.28 respectively,which were all statistically different from those of older adults with normal cognitive function.2.A total of six RCTs and 1039 participates were included.In terms of global cognitive function,the result of meta-analysis showed that the global compositez-score [SMD= 0.23,95%CI(0.1,0.36),P=0.0004] exhibited statistical difference between the intervention group and the control group.There were no statistical differences on MMSE scores,Memory,Executive Function,Attention,and Information Processing Speed across groupsConclusions1.The results show that the prevalence of MCI is relatively high in the elderly aged 65 and above,which gradually appear with the increase of age,while the higher education level,economic income and moderate physical activity correspond to better cognitive performance.2.The current evidence shows that nutrition and exercise interventions could ameliorate cognitive function in the aged with cognitive decline.Further studies with longer follow-up time should pay more attention to the randomness,credibility and scale of the experiment,which can confirm the effect of nutrition-combined exercise intervention,particularly in older adults.