The Relationship Between Intravoxel Incoherent Motion And Microvessel Density And Pathological Grading Of Cervical Cancer

Objective:To analyse the value of intravoxel incoherent motion(IVIM)diffusion weighted imaging and histological microvessel density(MVD)in grading of cervical cancer and to investigate their correlation.Methods:26 patients with pathologically proved cervical cancer were analysed retrospectively.They were divided into G1 group(highly differentiated),G2group(moderately differentiated)and G3 group(poorly differentiated)according to pathology grading of cervical cancer.All patients underwent IVIM MRI.The IVIM parameters(ADC?D?D~*?f?fD~*)were assessed.And these parameters were correlated with MVD.The MVD were determined with the CD34 stain.Kruskal-Wallis H test was used to compare differences of parameters among three groups.Spearman's rank correlation analysis was used to evaluate the correlation of parameters and pathology grading and the correlation between IVIM parameters and MVD.Results:All the IVIM parameters showed statistical difference among three groups.Pairwise comparison showed that D had significant difference.Comparing with G1and G3?G2 and G3,D*value shows significant difference.D value decreased with the increase of differentiation level(that is,the lowest median value of D value in the low-differentiation group);While the value of D*decreases gradually with the increase of differentiation level.The MVD was statistically significant among the three groups.The correlation between IVIM parameters D*value and MVD was statistically significant,showing a linear correlation.Conclusion:IVIM parameters(D?D*)and MVD have certain diagnostic value for cervical cancer grading.Besides,D*might be used in the noninvasive evalution of MVD.