Analysis Of Risk Factors For Morbidity And Severity Of Disease In Patients With Primary Biliary Cirrhosis

Objective:To investigate whether the number and sex of children of female PBC patients were correlated with the incidence and severity of disease.Methods :A total of 295 female PBC patients who met the diagnostic criteria and had children were collected from patients treated at shengjing hospital affiliated to China medical university from 2007 to 2019.Case data: age at first diagnosis,cirrhosis at first diagnosis,total number of children and number of boys and girls.The patients were divided into two groups according to the age of initial diagnosis and the presence or absence of cirrhosis.Through single factor analysis,chi-square test was used to compare the clinical data of different groups of patients,and p ? 0.05 was considered as statistically significant.Logistic regression multi-factor analysis was used to analyze the relationship between PBC incidence and disease severity.Results:A total of 295 cases were included in this study,including 187 patients with single children(number of children = 1),108 patients with multiple children(number of children> 1),251 patients with boys,and patients with girls There are 241.According to the results of the overall case analysis,the P value of the number of children,the sex ratio of the children and the gender composition between the different age groups and the severity of the disease is less than 0.05,and the difference is statistically significant.In the analysis and comparison of the sex of children,because most of the patients in the collected cases have both boys and girls,so the sex of the children is divided into the sex ratio and composition of the children for analysis and comparison.The sex ratio of children is divided into multiple boys,multiple girls and men and women according to the number of boys and girls.The gender composition of children is divided into boys,girls and boys plus girls according to all gender categories in children.The proportion of patients with multiple boys(49.5%)and only boys(48.6%)in the low age group was higher than other age groups.Further logistic regression analysis showed that only boys(P < 0.05,OR = 0.025)patients have a higher risk of early onset than patients with other children of gender composition.The proportion of patients with more boys(43%)and only boys(40.9%)in the liver cirrhosis group was significantly higher than that in the non-cirrhotic group.Further logistic regression analysis showed that only boys were born(P <0.05,OR = 4.924)The risk of cirrhosis is higher at the initial diagnosis.The analysis of the overall cases does not show that multiple children are risk factors that affect the incidence of PBC and the severity of the disease.Further analysis of patients with cirrhosis and PBC patients with low age at the time of initial diagnosis.According to the analysis results of patients who had cirrhosis at the first diagnosis,the P value of different children and the gender composition of children at different initial diagnosis age groups was less than 0.05.There was a significant difference.As the age of initial diagnosis decreased,there were many children and The proportion of PBC patients with only boys increased,and the results of ordered logistic regression analysis showed that they had more children than those with single children and other genders(P <0.05,OR = 0.476)and only had Boys(P <0.05,OR = 0.063)have a higher risk of early-onset PBC patients.According to the analysis results of PBC patients with young age at first diagnosis,the P values of different children,sex ratio and composition of children in different age groups and severity of onset are all less than 0.05.The difference is statistically significant.The proportion of patients with multiple children(65.9%),only boys(52.2%),and with multiple boys(50.0%)was higher than that in the non-cirrhotic group.Further Logistic analysis showed that those with single children and other genders Patients had a higher risk of cirrhosis at the time of onset than PBC patients with multiple children(P <0.05,OR = 3.611).Conclusion:The incidence and severity of PBC patients are related to the number of children and their gender.Having a boy is a risk factor that affects the severity of PBC disease.Among the PBC patients who had cirrhosis at the time of initial diagnosis,there were correlations between having children and having boys and having children,and those with many children had a higher risk of early onset.Among PBC patients with young age at the first diagnosis,there are correlations between multiple children and the severity of their disease.PBC patients with multiple children have a higher risk of developing cirrhosis.