Imaging Of ¹⁸F-FDG PET/CT In Adult-onset Still's Disease And Its Role In The Assessment Of Disease Activity

Objective:To investigate¹⁸F-FDG PET/CT in patients with adult-onset Still's disease?AOSD?imaging and its role in disease activity.Methods:45 patients who was diagnosed as AOSD were selected and underwent¹⁸F-FDG PET/CT.The clinical manifestations,laboratory examination and characteristics of ¹⁸F-FDG PET/CT were collected.Then the correlation between SUV intensity of spleen,bone marrow,lymph node and laboratory indexes,system scores were analyzed.At the same time,20 patients who underwent ¹⁸F-FDG PET/CT examination in our hospital were collected.The measurement data were expressed as X±S in accordance with normal distribution,and t-test was used for comparison between groups.If the distribution is non-normal,the median is used,and the rank-sum test is used for inter-group comparison.Results:¹⁸F-FDG accumulation occurred mainly in bone marrow?100%,SUV intensity:2.02±0.66?,Spleen?96%,SUV intensity:1.72±0.53?and lymph nodes?98%,SUV intensity:2.70±1.39?.The SUV intensity of bone marrow?lymphoma and spleen in the AOSD group was higher than that in the control group?P<0.05?.In addition,¹⁸F-FDG uptake can also occur in the pericardial pleural,parotid gland,thyroid,skin,joint esophagus and cardia.SUV intensity of bone marrow was significantly correlated with systemic score,ESR,c-reactive protein,WBC and NEU%?r=0.423?0.414?0.450?0.373?0.415,P<0.05?.SUV intensity of Spleen was significantly correlated with system score and LDH?r=0.423?0.304,P<0.05?.SUV intensity of Lymph node was significantly correlated with disease system score?r=0.321,P<0.05?.Conclusions:¹⁸F-FDG accumulation occurred mainly in bone marrow,spleen and lymph nodes.¹⁸F-FDG PET/CT may is helpful for monitoring of disease activity.