Comparative Analysis Of Risk Factors At PICU Patients With Aminoglycoside Resistant In Mdrab Infection

Background: The multidrug resistance Acinetobacter baumannii(MDRAB)remains the major causes of nosocomial infection especially in pediatric intensive care unit(PICU).Aminoglycoside is one of first drug of choice used to treat severe infection caused by A.baumannii and emergence of ARAB has recently developed.Objective: To identify the risk factors for nosocomial Aminoglycoside resistant Acinetobacter baumannii(ARAB)infections in both sensitive and resistance strains from pediatric intensive care units(PICU).Materials and Method: In this study a total of 311 A.baumannii clinical isolates were collected from PICU Shengjing hospital of China medical university from 2014 to 2018.Antimicrobial susceptibility testing was performed by E test method.Results: In 311 isolates,almost all the strains 97.8%(293/311)had full resistance to at least one or more of the tested antibiotics;the most resistance was observed in the meropenem 77.5%,levofloxacin 71.3%,gentamycin70%,and tetracycline 57.1% while amikacin 11.3% and cefoperazone/sulbactam were seen as the most active drug in this study.The age,others antibiotics broad-spectrum use before A.baumannii culture results,interventional operation and total hospital stay was significantly associated with ARABs(P ? 0.05).Conclusion: Our results suggest that the nosocomial occurrence of ARAB is strongly related to age,others antibiotics broad-spectrum use before A.baumannii culture results,interventional operation and total hospital stay.