The Expression And Significance Of Complete Blood Count And Their Derived Parameters In Endometriosis

Objective:To investigate the value of blood cells and their derived parameters in the diagnosis of ectopic ovarian cyst/adenomyosis and their correlation with clinical features.Methods:83 cases of patients receiving adenomyosis surgery(adenomyosis group),72 cases of patients receiving ectopic ovarian cyst surgery(ectopic ovarian cyst group)and 74 cases of other benign ovarian tumors(control group)were collected from shengjing hospital affiliated to China medical university.Peripheral blood was extracted and blood cells and serum CA125 levels were detected,the correlation between blood cell,their derived markers neutrophil to lymphocyte ratio(NLR)?platelet to lymphocyte ratio(PLR)? monocyte to lymphocyte ratio(MLR)?eosinophils to lymphocyte ratio(ELR)? basophils to lymphocyte ratio(ELR)?derived neutrophil to lymphocyte ratio(d NLR)?systemic immune-inflammation index(SII)? systemic inflammation response index(SIRI),CA125 and ectopic ovarian cyst/adenomyosis was analyzed.Results:1.NLR?SII?CA125 of patients with ectopic ovarian cyst and patients with adenomyosis were all significantly higher than those in healthy controls(all P<0.05).SII was significantly higher in adenomyosis group than in ectopic ovarian cyst group,NLR and CA125 showed no significant difference between adenomyosis group and ectopic ovarian cyst group.2.PLT ? MLR ? SIRI ? d NLR ? PLR ? BLR were significantly higher in the adenomyosis group than in the control group,and the difference was statistically significant(p <0.05).there was no significant difference between the ovarian ectopic cyst group and the control group.LYM was significantly lower in adenomyosis group than in control group and ovarian ectopic cyst group(P <0.05),and there was no significant difference between ovarian ectopic cyst group and control group.3.In the ovarian ectopic cyst group,NLR?SII?CA125 were not significantly associated with pain and clinical stage.In the adenomyosis group,PLR?SII?PLT were positively correlated with uterine volume and were not associated with pain.4.In the ovarian ectopic cyst group,the diagnostic value of CA125 was higher than that of NLR,SII,and the combination of CA125 with NLR or SII did not improve its diagnostic value.In the adenomyosis group,the area under curve(AUC)of CA125,PLR and SII was greater than 0.7,and the value of auxiliary diagnosis of disease was higher,and the AUC of PLR and NLR for the diagnosis of adenomyosis in combination with CA125 was greater than 0.9,which was significantly higher than that of CA125 alone(AUC=0.873).Conclusion:The blood cell-derived inflammatory parameters can be used for inflammatory prediction and condition evaluation of adenomyosis/ovarian ectopic cysts,providing the basis for clinical diagnosis and treatment of endometriosis.PLR and SII have high diagnostic value for adenomyosis and are positively correlated with uterine volume size in patients with adenomyosis,which can reflect disease progression and its severity,and may be analternative diagnostic and monitoring indicator for CA125.