Therapeutic Effect Of Radiotherapy On Lymph Node Metastasis In Recurrent Gynecological Malignancies

Objective: To observe the effect of radiotherapy on lymphatic metastasis of recurrent gynecological malignancies.Methods:This article selected 58 patients with recurrent gynecological malignant lymph node metastasis who were seen in the hospital from July 2011 to July 2018.The efficacy analysis was performed by comparing the imaging examination confirmed before the radiotherapy and the review one month after the end of the radiotherapy.Grouped according to the number of lymph node metastases,different radiotherapy doses,and different treatment methods.Through follow-up,observe the remission rate and control rate of the overall patients and patients grouped in different ways after radiotherapy,median PFS,average OS,and summarize their efficacy.Results:All 58 patients successfully completed the treatment.The total response rate was 56.9%(33/58),the total control rate was 84.48%,the local control rate was86.21%,the median PFS was 17 months,and the average OS was 60.63 months.Grouped by the number of metastatic lymph nodes,the response rate in the group of<= 3 lymph node metastases was 60.98%,the control rate was 92.68%,and the response rate in the metastatic lymph nodes> 3 groups was 47.06%,the control rate was 64.71%.There was statistical significance,and there was no significant difference between the two groups in patients with distant metastases.There were no significant differences in the response rate,control rate,median PFS,and average OS of patients with lymph node metastasis by radiotherapy dose grouping and treatment methods(P> 0.05).Conclusion:Radiotherapy can effectively control the progression of lymph node metastasis in recurrent gynecological malignancies and prolong survival.The number of lymph node metastases may be a risk factor that affects the efficacy of radiotherapy and progression-free survival time.When the minimum effective dose is reached,increasing the radiotherapy dose cannot improve the efficacy or prolong the survival time,and there are no significant differences in adverse reactions.Compared with patients receiving radiotherapy alone,radiotherapy combined with chemotherapy could not improve the disease control rate or prolong the survival time of patients,and there were no significant differences in adverse reactions between the two.Precise radiotherapy,while ensuring the efficacy,has minor side effects,and the patient is easy to receive treatment,which is more suitable for clinical application.