Clinical Observation On The Effect Of Malongzhixiao Prescription On Chronic Duration Of Bronchial Asthma(wind Phlegm Obstruction Lung)and Its Effect On FeNO And Peripheral Blood Eosinophil

Objective: To observe the Clinical effect of MACHANZHIXIAO prescription on chronic duration of bronchial asthma(wind phlegm obstruction lung)and its effect on Fe NO and Peripheral Blood eosinophil.Methods: 70 cases of chronic duration of bronchial asthma were chosen from the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine clinic(wind phlegm obstruction lung)were randomly divided into treatment group(35 cases)and control group(35 cases).The treatment group was given MACHANZHIXIAO prescription,the control group was treated with Budesonide and Formoterol Fumarate Powder for Inhalation.The course of treatment was 14 days.To observe the changes of the scores of sympto-ms,signs,total score of TCM syndrome s,pulmonary function,fraction ofexhaled nitric oxide,peripheral blood eosinophil count before and after medication.Results:1.The clinical efficacy of MACHANZHIXIAO decoction in the treatmentof chronic duration of bronchial asthma(wind-phlegm-obstructed lung syndrome)was significant,with the total effective rate of 94.12%,which was statistically significant compared with the control group(P<0.05).The efficacy was significantly better than that of the control group,with no adverse reactions.2.Both the two groups could effectively improve the total score an d indivi-dual score of TCM syndromes of patients,and the comparison b efore an-d after treatment was statistically significant(P<0.05),and the i mprovem-ent of wheezing,shortness of breath,cough and white sputum in the experimental group was betterthan that in the control group(P<0.05),while there was no significant difference between the other sympto m groups(P>0.05).3.The two groups of drugs can improve the value of FEV1 before and after treatment,and the difference between the two groups is no significant(P>0.05),but there is no significant difference between the two groups(P>0.05).However,the two groups of drugs had no effect ont he FEV1/FVC value of patients before and after treatment,and the difference was not significant(P>0.05).4.Both groups of drugs could effectively improve the fraction of exhaled nitric oxide value of patients,the comparison before and after treatment has statistical significance(P<0.05),and the comparison between groups after treatment is significant(P>0.05),the degree of improvement in the treatment group is better than the control group.5.The drugs effectively reduced the peripheral blood eosinophil count and peripheral blood eosinophil percentage in both groups,and the comparison before and after treatment was statistically significant(P<0.05).After treatment,the comparison between groups was not statistically significant(P>0.05).Conclusion:1.MACHANZHIXIAO decoction has remarkable clinical efficacy in the treatment of chronic duration of bronchial asthma(wind-phlegm obstructing lung syndrome)especially in wheezing and hyperventilation.2.MACHANZHIXIAO decoction can effectively reduce peripheral b-lood eosinophil count and peripheral blood eosinophil percentage and fraction of exhaled nitric oxide count.