Analysis Of The Status Of Hepatitis C Virus Infection And Genotype Distribution In Sichuan Province

OBJECTIVE: To investigate the HCV infection,basic epidemic characteristics and genotype distribution in Sichuan Province.METHODS: The viral load of HCV-RNA in blood samples from 4465 patients in the Sichuan Provincial People's Hospital was analyzed by retrospective study from 2014 to 2018.At the same time,the HCV genotyping of 467 patient blood samples collected from 2016 to 2018 based on PCR-fluorescent probe typing was analyzed.RESULTS: 1647 positive cases were confirmed by high precision HCV-RNA quantitative test,the positive rate was 36.89%(95% confidence interval: 35.47-38.31%),of which 813 were male and the positive rate was 49.36%;the female was 834,the positive rate was 50.64%.Among the positive patients,55.74% were 41-60 years old,and the positive rates in the 41-60 age group in the five years(2014-2018)were 50.00%,57.94%,55.97%,55.51% and 54.08%,respectively.From 2014 to 2018,the positive rates of HCV-RNA quantitative tests were 49.28%,48.98%,39.83%,30.47%and 31.36%,respectively.Of the 467 HCV-RNA positive serum specimens from 2016 to 2018,355 cases(76.02%)of type 1b were predominated,with 166 males(46.76%)and 189 females(53.25%).CONCLUSIONS: From 2014 to 2018,the positive rate of HCV-RNA detected in the Sichuan Provincial People's Hospital showed a decreasing trend year by year,while the positive rate of patients aged 41-60 years old showed a rising trend year by year.The HCV epidemic genotypes in Sichuan area showed the distribution characteristics of multiple genotypes,mainly cases were type 1b.Understanding the basic situation of HCV-infected patients and common classification is of great value for clinical detection and treatment.