Study In Preparation And In Vitro Of Curcumin Microneedles

Objective In order to solve the problem of poor water solubility and low bioavailability of curcumin,curcumin was prepared into solid dispersion.To characterize its appearance and morphology the formation of solid dispersion.The dissolution rate within 120 min and the in vitro transdermal condition within 12 h were investigated.Methods By using Povidone?PVP K30?,Polyethylene glycol 6000?PEG 6000?,Poloxamer188?inset polyether f-68,F 68?as carrier matrix,curcumin was first prepared into solid dispersion by melting method,and then curcumin solid dispersion was poured into microneedle mold in molten state and by forcing to make it being microneedle.It was identified by scanning electron microscopy,differential scanning calorimetry and infrared spectroscopy.And its dissolution in 0.2%sodium dodecyl sulfate?SDS?solution for 120 min was investigated by ultraviolet spectrophotometry.In addition,to investigate its in vitro transdermal condition by using vertical Franz diffusion pool.And In vitro transdermal penetration was determined by HPLC within12 h.Results The microneedle forming degree of the three materials was good.Scanning electron microscopy,differential scanning calorimetry and infrared spectroscopy analysis results all showed that curcumin existed in the carrier matrix in an amorphous form.The results of the dissolution experiment also showed that the dissolution of curcumin within 120 min was significantly improved when curcumin was prepared into solid dispersion.Within 120 min in 0.2%SDS solution,the cumulative dissolution of 10%PVP K30 curcumin solid dispersion microneedle could reach to 65.71%,that of 10%PEG 6000 curcumin solid dispersion microneedle could reach to 60.49%,and that of 10%Proloxam 188 curcumin solid dispersion microneedle could reach to 60.93%.However,under the same conditions,the cumulative dissolution of curcumin powder only could reach to 24.66%.The results of in vitro transdermal experiments showed that the cumulative osmotic volume of PVP K30 microneedles could reach to 7.098 g·cm^-2and skin retention could reach to 57.067 g·cm^-2within 12 h.The PEG 6000 microneedles could reach to 8.532 g·cm^-2and the skin retention could reach to 54.705 g·cm^-2.The poloxamer 188 microneedles could reach to 54.705 g·cm^-2and the skin retention could reach to 7.795 g·cm^-2.But the solid dispersion of curcumin does not have obvious transdermal effect,because the curcumin content cannot be detected in the receiving solution.Therefore,it can be explained that curcumin solid dispersion microne significantly improved the transdermal effect of curcumin solid dispersion.Conclusion Curcumin solid dispersion microneeses can achieve the effect of skin puncture in vitro,and PVP K30 as microneedle matrix is comprehensively evaluated to have the best effect in this experiment.In this paper,curcumin was made into solid dispersible microneedles,which significantly improved the solubility and percutaneous permeability of curcumin,and provided certain research basis for the percutaneous preparation of water-insoluble drugs.