Study On Activation Degree Of Superior Temporal Gyrus Under Pure Tone Stimulation

In recent years,with the rapid development of technology,many new technologies and methods have appeared.Blood oxygen level dependent-functional magnetic resonance imaging(BOLD-fMRI)is a new neuroimaging method,to observe the neural activity of human brain in a non-invasive way,which has made great progress in the research of brain science.The superior temporal gyrus participates in high-level auditory processing of speech and plays a key role in speech processing.Pure tone refers to sound with a single frequency component.In the related research of auditory,pure tone is the most commonly used sound stimulus.In this context,this article studies the topic of "activation degree of the superior temporal gyrus under pure tone stimulation".BOLD-fMRI is a powerful method for studying brain function.Its principle is to use magnetic resonance imaging to measure the hemodynamic changes caused by neuron activity.Its method is to make each functional area of the cerebral cortex image on magnetic resonance equipment through certain stimulation.It combines three aspects of function,imaging and anatomy,which is an effective method to locate functional areas in the living human brain.In this paper,the MRI scan data of the superior temporal gyrus in 33 subjects(16 males,17 females,19-26 years old)under six different frequencies(200Hz,400 Hz,800Hz,1600 Hz,3200Hz,and 6400Hz)pure tone stimulation were collected by BOLD-fMRI technology.The stimulus materials were played through the E-prime software.The collected raw data was processed using SPM8 software and the resting state data was used as a baseline for statistical and analysis.The paper has carried out the following work:(1)Analyze the statistical results about the activation degree of the superior temporal gyrus under six frequencies pure tone stimulation,and compare the activation differences from the two dimensions of activation extent and activation intensity;(2)In order to more visually observe the activation distribution of the superior temporal gyrus under six frequencies pure tone stimulation,the activation brain map was drawn;(3)Further analyzed the voxels whose activation intensity values reached the top 10%,20%,and 50%,respectively,and plotted the activation brain map of the superior temporal gyrus at a certain threshold under low frequency,intermediate frequency and high frequency pure tone stimulation;(4)Finally,whether the activation difference of the superior temporal gyrus can be used as a feature to classify low frequency,intermediate frequency,and high frequency pure-tone stimulation by multi-voxel pattern analysis(MVPA)is explored.The results obtained in the paper show that:(1)The activation intensity and extent of the superior temporal gyrus under 200 Hz pure tone stimulation are significantly higher than other frequencies,and the activation differences of the pure tone stimulation for the remaining five frequencies are not significant;(2)The stronger the activation intensity,the greater the activation extent.Also,the activation intensity and activation extent have a linear positive correlation;(3)The top 10%,20%,and 50% of activated voxels at low frequency,intermediate frequency and high frequency are partially overlapped.And the more we take,the bigger the overlap.Among which the overlap under the top 10% of activation is the least.(4)The top 10% of activated voxels can be used to distinguish low frequency,intermediate frequency and high frequency pure tone stimulation through MVPA.In a word,this paper studies the activation intensity,activation extent and their correlation of superior temporal gyrus under pure tone stimulation,and draws the conclusion that low frequency,medium frequency and high frequency pure tone stimulation can be distinguished by multi voxel pattern analysis,which is characterized by the top 10% of activated voxels.Decoding the superior temporal gyrus can restore the pure tone frequency to be heard.It has a certain research value for pure tone frequency discrimination and pure tone audiometry.It provides a simple and easy-to-use reference method for decoding cognitive state from neural signals,and provides a reference for the research of similar classification and recognition problems.At the same time,it has a certain reference value for the judgment of hearing loss and the choice of stimulus materials in the treatment of depression and epilepsy.