Brain Micro-structure Alteration In Patients With Idiopathic Central Precocious Puberty By VBM And TBSS Analysis

Background Idiopathic central precocious puberty(ICPP)is one of the most common types of abnormal growing development in children's puberty.The main pathogenesis is that regulatory function of the hypothalamus-Pituitary-Gonadal Axis(HPGA)was early activated.The main characteristics is various morphological changes of mammary gland,gonad and externalia.Nowadays,people's living quality has been improved to a large extent compared with the past.It is very general phenomenon for children to come to the hospital with precocious puberty,which has formed a serious obstacle in the growth period of children.So,the research on ICPP patients has been paid more and more attention by the medical community at home and abroad.However,the simple and common scanning sequences of computed tomography(CT)and magnetic resonance imaging(MRI)can only detect large lesions or significant abnormal density/signal,not clear images of the brain's internal subtle structure,So the damage of the brain micro-structure unable to be found.Nevertheless,with the rapid development of multi-mode magnetic resonance(m MRI)imaging technology at present,it has provided vital thought for the diagnosis and therapy of a variety of clinical diseases.However,voxel-based Morphometry(VBM)and Diffusion Tensor Imaging(DTI)in m MRI have become the most reliable and universal imaging method to observe brain micro-structures depending on their Imaging advantages.which is sensitive and noninvasive to find early damage with brain structures,and datum collection is easy to operate and can be used many times,to study the differences in brain gray matter volume and white matter fiber tracts from a microscopic perspective,so as to further speculate whether there is some special correlationbetween micro-structure damage and endocrine dysfunction of HPGA in patients.At present,studies on the application of VBM and DTI imaging technology in ICPP are still lacking.Objective VBM combined with DTI method were used to observe the changes of gray matter volume and the destruction of the structural integrity of cerebral white matter fiber bundles in patients with idiopathic central precocity,and to investigate the effect of the changes on HPGA.Methods In this study,The numbers of ICPP patients were 21 that were diagnosed in pediatrics in our hospital who met the diagnostic criteria for precocious puberty in China and same numbers of normal control group matched by age and gender were included.Using 3.0 T MR machine to scan and collect the brain micro-structure image data from the original image and the DTI datum,Application of VBM and based on the fiber bundle tracer method of spatial statistics(TBSS)to find and analyze of gray matter volume and the difference values of white matter fiber tracts anisotropic(FA)between different group participants,and to speculate the correlation between micro-structure damage and endocrine dysfunction of HPGA in patients Results The children of ICPP group compared with the normal group,the volume of gray matter in the posterior central gyrus of the brain decreased in the patients with idiopathic central precocious puberty(P < 0.05).And the structure of white matter fiber bundles in both hemispheres were found in left anterior corona radiata,both sides anterior thalamic radiation,forceps minor was destroyed(P<0.05).Conclusion Several white matter micro-structure's disruption and the center posterior of brain gray-matter volume's change were found in the patients withidiopathic central precocious puberty,The distinct variation is in the left.And through preliminary speculate that brain structural damage is related to the endocrine dysfunction of HPGA.