Study On The Relationship Between Pulmonary Arterial Hypertension And Abdominal Aortic Calcification In Peritoneal Dialysis Patients

Objective: To investigate the prevalence of pulmonary artery hypertension in patients with single-center peritoneal dialysis and to explore the relationship between pulmonary artery hypertension and abdominal aortic calcification in patients with peritoneal dialysis.Methods: Selected regular peritoneal dialysis patients who were followed up in the Department of Nephrology of the second affiliated Hospital of Anhui Medical University from January 2016 to December 2018.Include age,sex,diabetes history,systolic blood pressure,diastolic blood pressure,dialysis age,body mass index,hemoglobin,blood calcium(corrected blood calcium),phosphorus,creatinine,brain natriuretic peptide,parathyroid hormone,albumin,total cholesterol,triglyceride,total urea clearance index,left ventricular diastolic dimension,Left atrial diastolic dimension,left ventricular ejection fraction,pulmonary artery pressure and abdominal lateral plain film.According to whether peritoneal dialysis patients were complicated with pulmonary arterial hypertension,the patients were divided into pulmonary arterial hypertension group and non-pulmonary arterial hypertension group,to investigate the prevalence of pulmonary artery hypertension in patients with peritoneal dialysis and to explore the relationship between pulmonary artery hypertension and abdominal aortic calcification in patients with peritoneal dialysis.Results: Results A total of 111 patients were included in the study,including 33 patients with pulmonary arterial hypertension and 78 patients with non-pulmonaryarterial hypertension.Two groups of patients in hemoglobin(96.32±20.91vs82.73±16.03,P=0.001),creatinine(854.4±310.30 vs 1011.79±355.67,P=0.021),left ventricular diastolic dimension(46.45±6.45 vs 49.24±7.48,P=0.049),left atrium diastolic dimension(32.87±5.86 vs 38.73±7.55,P<0.001),left ventricular ejection fraction(60.77±4.09 vs 58.86 ±5.27,P=0.041),and total urea clearance index(2.21±0.98 vs 1.83±0.58,P=0.040)and parathyroid hormone {216.50(79.90,366.50)vs 392.00(186.00,609.00),P=0.010},triglycerides {1.59(0.94,2.31)vs 1.03(0.76,1.88),P=0.034},abdominal aortic calcification(33 vs 21,P=0.040)has a difference.Spearman correlation analysis showed that pulmonary arterial hypertension was positively correlated with creatinine(r=0.203,P=0.032),parathyroid hormone(r=0.256,P=0.007),left ventricular diastolic dimension(r=0.188,P=0.048),left atrium diastolic dimension(r=0.389,P<0.001),and abdominal aorta calcification(r=0.195,P=0.040);It was negatively correlated with hemoglobin(r=-0.278,P=0.003),triglyceride(r=-0.202,P=0.033)and total urea clearance index(r=-0.212,P=0.026).Logistic regression analysis showed that abdominal aortic calcification(OR=5.607,P=0.016),high left atrial diastolic dimension(OR=1.289,P<0.001)and low hemoglobin(OR=0.960,P=0.029)were risk factors for pulmonary arterial hypertension.Conclusions: 1.In this study,it can be concluded that 29.73% of patients with peritoneal dialysis complicated with pulmonary arterial hypertension.2.At the same time,this study found that abdominal aortic calcification,high left atrium diastolic dimension and low hemoglobin were independent risk factors for pulmonary arterial hypertension in peritoneal dialysis patients.