Association Of Blood Lead And Blood Strontium With Hypertension In People Aged 60 And Above In Lu 'an City

Objective In this study,the prevalence of hypertension in the population over 60 years old was investigated in western Anhui,China.Strontium and lead were detected in the whole blood of the subjects to investigate strontium and lead exposure in elderly populations in the area.And to explore the relationship between blood lead and blood strontium in humans and the risk of hypertension and blood pressure levels.Provide the direction of early prevention for the prevention and treatment of hypertension in the elderly.Methods In west Anhui areas of China in 2016,this study investigated the elderly population in two local communities through stratified cluster sampling,and included1013 people.The general socio-demographic characteristics,lifestyle,disease history and physical examination information of the respondents were collected by a combination of face-to-face survey and physical examination by investigators who had been uniformly trained and examined.The concentrations of strontium and lead in whole blood were measured by an inductively coupled plasma mass spectrometer.Pearson's chi-square test was used to evaluate the significance of prevalence of hypertension difference among different population and behavioral characteristics.Mann-Whitney U Test was used to compare the concentrations of blood Sr and blood Pb among the different population and behavioral characteristics.Logistic regression models were used to assess the relationship between blood lead and blood strontium and the risk of hypertension.Pearson correlation was used to analyze the correlation between blood strontium and lead and blood pressure levels after Ln conversion.The relationship between the concentration of strontium and lead in whole blood and blood pressure was investigated by using multiple linear regression model.Four models were used to analyze the relationship between combined exposure of strontium and lead to the risk of hypertension.Results This study participants included 1013 subjects,of which 725 hypertension patients?71.6%?,the population average age of 71.70±6.37 years,including 461 men?45.5%?,552 women?54.5%?.There were statistically significant differences in the prevalence of hypertension between BMI group,waist circumference group and occupation group.The sedentary time,CHOL,TG and HDL-C were higher in the hypertension group than in the non-hypertension group.The concentrations of blood lead and blood strontium were statistically different among the education level,per capita income,occupational,BMI,physical exercise,alcohol consumption and hypertension groups.Logistic regression analysis showed that after adjusting for confounding factors,the odd ratio of hypertension in the highest quartile groups of blood Pb concentrations were 2.08(95%CI:1.31-3.30,P_trend=0.002),when compared with those in the lowest quartile group;The risk of high SBP in the highest quartile of blood Pb concentration was 1.67(95%CI:1.11-2.51,P_trend=0.020)by using the lowest quartile as a reference;The relative risk of high DBP comparing highest and lowest quartile of blood Pb concentration were 1.60(95%CI:1.01-2.53,P_trend=0.024).The risk of hypertension in the highest quartile of blood Sr concentration was 1.72(95%CI:1.11-2.68,P_trend=0.014)by using the lowest quartile as a reference;The relative risk of high SBP comparing highest and lowest quartile of blood Sr concentration were 1.51(95%CI:1.02-2.24,P_trend=0.017);Multiple linear regression analysis shows that after adjusting covariates,Ln Pb level was positively correlated with both systolic and diastolic blood pressure??=4.27,95%Cl:1.22-7.32,P=0.006?,??=2.18,95%Cl:0.63-3.73,P=0.006?;Ln Sr level was positively correlated with systolic blood pressure??=7.05,95%Cl:2.89-11.22,P=0.001?.Logistic regression analysis showed that combined exposure to Sr and Pb was associated with increased risk of hypertension and systolic blood pressure level.Conclusions This study found that the blood lead and blood strontium may be associated with increase risk of hypertension.Blood lead levels may be related to the increase of systolic and diastolic blood pressure,while the Serum strontium levels may be related to the increase of systolic blood pressure.Combined exposure to lead and strontium can increase the risk of hypertension by affecting systolic blood pressure.This study provides data to support the association between blood lead and strontium levels and hypertension in the elderly population.The results need to be confirmed in further animal studies and cohort studies.