Efficacy Analysis Of Drospirenone Ethinylestradiol Tablets (?) In The Treatment Of Polycystic Ovary Syndrome

Objective:To explore the clinical effect of the new compound oral contraceptive(COC)drospironone ethinylestradiol(?)in the treatment of polycystic ovarian syndrome(PCOS),and to provide theoretical basis for the drug treatment of PCOS.Methods:Ninety patients who were first diagnosed with PCOS in the gynecological outpatient clinic of the First Affiliated Hospital of Kunming Medical University from June 2018 toThree 2019 were selected as the study subjects,and randomly divided into observation group and control group,with 45 cases in observation group and 45 cases in control group.Body mass index(BMI),six items of sex hormones,five items of fasting plasma glucose(FPG)and blood lipids were measured before treatment in all patients,and LH/FSH,TG/HDL-C ratio,hirsutism score and acne grade were calculated.The observation group was treated with drospirenone ethinylestradiol tablets(?)for six cycles,and the control group was treated with ethinylestradiol cyproterone tablets for six cycles.During the treatment period,adverse reactions of patients were observed.The above indicators were reviewed after six cycles,and the clinical effects and adverse reactions of drospirenone and ethinylestradiol tablets(?)in the treatment of PCOS were analyzed by comparing ethinylestradiol and cyproterone tablets.Results:1.Comparison of general conditions between the two groups before and after treatment:after treatment,the BMI of observation group was slightly lower than before(P>0.05),the difference was not statistically significant;after treatment,the BMI of control group was increased(P<0.05),the difference was statistically significant.2.Six items of sex hormones were compared between the two groups before and after treatment:after treatment,the values of LH,LH/FSH,E2 and T in the observation group and the control group were all decreased(P<0.05),and the difference was statistically significant;the values of LH and LH/FSH in the observation group were more significantly decreased than those in the control group(P<0.05),and the difference was statistically significant.There was no significant difference in the decrease of E2 and T values between the two groups(P>0.05).3.Comparison of lipid metabolism between the two groups before and after treatment:after treatment,FPG,TG and LDL-C values in the observation group were increased,while TG/HDL-C values were decreased,with no statistically significant difference(P>0.05);CHOL and HDL-C values were increased(P<0.05),with statistically significant difference.In the control group,FPG,CHOL,TG,HDL-C and LDL-C values increased,while TG/HDL-C values decreased,with statistically significant difference(P<0.05).In the control group,FPG,TG and LDL-C were significantly increased compared with the observation group,while TG/HDL-C was significantly decreased compared with the observation group.There was no significant difference in CHOL and HDL-C values between the observation group and the control group.4.Comparisons of adverse reac.tions between the two groups during treatment:during treatment,adverse reactions in the two groups were a little bleeding,dizziness,gastrointestinal reactions,breast tenderness.the adverse reactions of the observation group were spotting bleeding,with a total incidence of 14.29%and 14.62%in the control group.5.Comparison of menstrual recovery after treatment between the two groups:after treatment,menstruation in both groups was significantly improved,the effective rate was 92.86%in the observation group and 87.80%in the control group.6.Comparison of hairy score and acne grade between the two groups:after treatment,the hairy score of the observation group and the control group decreased compared with that before treatment(P<0.05),the difference was statistically significant,and the difference between the two groups was not statistically significant(P>0.05);the acne grade of the observation group was significantly lower than before(P<0.05),the difference was statistically significant,and the acne grade of the control group decreased unknown.Significant(P>0.05),no significant difference.Conclusion:Drospironone ethinylestradiol(?)can effectively improve the sex hormone level,menstrual cycle,hairy score and acne classification of PCOS patients with normal BMI and do not affect their BMI.It has little effect on blood lipid,slight adverse drug reactions and high safety.Its overall clinical effect is better than that of ethinylestradiol and cyproterone.It can be used as one of the treatment drugs for PCOS patients with normal BMI.