The Study Of ~1H-MRS On The Changes Of Cerebral Metabolism In Children OSAHS

Objective:To analyze the changes of brain metabolism and function in children with obstructive sleep apnea-hypopnea syndrome(OSAHS)by 1H magnetic resonance spectroscopy(1H-MRS).Methods:Magnetic resonance spectroscopy(1H-MRS)scanning and PSG were performed on 20 OSAHS patients and 20 NC patients.NAA/Cr,NAA/Cho,Cho/Cr ratio and lactate free(Lac)presence in bilateral frontal lobes of the two groups were recorded.The PSG test indexes of the two groups were recorded.Between-group differences in the metabolite levels were evaluated using analysis of two-sample t-test,and the linear correlation between brain metabolites and PSG was analyzed by OSAHS group.Results:Inthe frontal lobe,the NAA/Cr?NAA/Cho of the OSAHS(2.1925±0.1437?1.5861±0.1713,respectively)was decreased compared with the healthy(2.7901±0.1437?1.9745±0.1632).The Cho/Cr of the OSAHS(1.2937±0.1352)was increased compared with the healthy(1.1823±0.1925),the difference was statistically significant(P<0.0001?P=0.0001 and P=0.0031,respectively;P values were both less than 0.005).Lac peak was not detected in all.In OSAHS group,AHI was negatively correlated with NAA/Cr and NAA/Cho in bilateral frontal lobes(r=-0.635?-0.617,respectively;P=0.003?0.004,respectively),but not with Cho/Cr(r=0.029,P=0.904).MSaO2 was positively correlated with NAA/Cr and NAA/Cho in bilateral frontal lobes(r=0.630?0.640,respectively;P=0.001?0.002,respectively),but not with Cho/Cr(r=0.008,P=0.974).Conclusion:OSHAS can cause abnormal metabolism of bilateral frontal white matter in children;1H-MRS can monitor the changes of brain metabolism of OSAHS in children earlier,and provide objective imaging basis for studying the pathophysiological mechanism and clinical diagnosis and treatment of OSAHS brain damage in children.