| Objective:A retrospective analysis was made on the immune function indexes of children with bronchopneumonia,which provides theoretical basis for immunotherapy of pediatric bronchopneumonia.Methods:Researchers collected 216 cases of bronchopneumonia in the pediatric ward of the First Affiliated Hospital of Jishou University(xiangxi Prefecture People's Hospital)from May 1,2017 to April 30,2019.In terms of the different infection pathogens of the research subjects,they were divided into bacterial pneumonia group(n=68),viral pneumonia group(n=109),and mycoplasma pneumonia group(n=39);In terms of whether the subjects had wheezing symptoms and/or wheezing in the lungs,they were further divided into the wheezing group(n=132)and the non-wheezing group(n=84).All 216 cases were tested for serum immunoglobulin A(Ig A),immunoglobulin G(Ig G),immunoglobulin M(Ig M),the results of complement C3,complement C4and lymphocyte subsets by the methods of immunization rate scattering turbidimetric and flow cytometry technology,and then compare the infection of different pathogens,and the relationship between the severity of the disease and the changes in immune function in children.Results:1.General information of the child patients:The bacterial pneumonia group is between 1 month and 10 years old,the viral pneumonia group is between 1 month plus 13 days and 11 years old,and the mycoplasma pneumonia group is between 3 months plus 29 days and6 years old.The three groups were dominated by infants and young children.There was no statistically significant difference in the average age of the three groups and the incidence of bronchopneumonia at different ages(P>0.05);The severe group was between 1 month and 6years old,with 90.2%occurring in infants and young children,and 9.8%occurring in preschool age.The general group was between 1 month plus25 days and 11 years old,with 70.3%of those in infants and young children,and 26.1%of those in preschool age.The two groups were mainly infants and young children,and the differences in the mean age and the incidence of bronchopneumonia at different age stages were statistically significant(P<0.05).The wheezing group was from 1 month to 10 years old,and 83.3%occurred in infancy and early childhood,and15.2%occurred in preschool age.The non-wheezing group was aged from 2 month to 11 years old,61.9%occurred in infancy,and preschool age accounted for 33.3%.The two groups were mainly infants and young children,and the differences in the mean age and the incidence of bronchopneumonia at different age stages were statistically significant(P<0.05).However,there was no statistically significant difference in gender between patients with different pathogens and those with severe disease(P>0.05).2.The results showed that the serum Ig A level of bacterial pneumonia group and viral pneumonia group were lower than that of mycoplasma pneumonia group by comparing the immune function indexes of the three groups of children with bacterial pneumonia,viral pneumonia and mycoplasma pneumonia.The serum Ig M level of the viral pneumonia group was lower than that of the mycoplasma pneumonia group,and the difference was statistically significant(P<0.05).here was no statistically significant difference between Ig G,complement C3,complement C4,CD4~+T cells,CD8~+T cells,CD4~+/CD8~+ratio,B cells,and natural killer cells(NK)(P>0.05).3.Comparing the immune function of the normal group and the severe group,the results showed that the Ig A,Ig G,complement C3,CD8~+T cells of the normal group were higher than the severe group,and the B cells of the normal group were lower than the severe group,the difference was statistically significant(P<0.05).According to Ig M,complement C4,NK cells,CD4~+T cells,CD4~+/CD8~+ratio comparison,the difference was not statistically significant(P>0.05).4.By comparing the immune function between the wheezing group and the non-wheezing group,the results showed that the Ig A,Ig G,and CD8~+T cells in the wheezing group were lower than those in the non-wheezing group.Statistical significance(P<0.05).Compared with Ig M,complement C3,complement C4,B cells and NK cells,the differences were not statistically significant(P>0.05).Further stratified analysis of the infected pathogens in the children revealed that:1.For children with bacterial pneumonia,the B cells in the severe group were higher than the normal group,the complement C3 was lower than the normal group,and the CD8~+T cells in the wheezing group were lower than those in the non-wheezing group,the difference was statistically significant(P<0.05);No statistical significance was found in the comparison of other indexes(P>0.05).2.For children with viral pneumonia,the Ig A,Ig G,NK cells,and CD8~+T cells in the severe group were lower than those in the normal group,the ratio of CD4~+/CD8~+far exceeded that in the normal group,and the Ig A,Ig G,and CD8~+T cells in the wheezing group were lower In the wheezing group,the CD4~+/CD8~+ratio in the wheezing group was higher than that in the non-wheezing group,and the difference was statistically significant(P<0.05);There was no obvious statistical significance in other indexes(P>0.05).3.For children with mycoplasma pneumonia,the B cells in the severe group were higher than the normal group,and the CD4~+T cells were lower than the normal group,the difference was statistically significant(P<0.05);No statistical significance was found in the other indexes(P>0.05);There was no statistically significant difference in all indexes between the wheezing group and the non-wheezing group(P>0.05).Conclusions:1.Children with bronchopneumonia infected by different pathogens have nothing to do with age and gender,but the severity of bronchopneumonia depends on age.Severe pneumonia is more likely to occur in children under 3 years old,and bronchial pneumonia with wheezing symptoms mostly occurs in children under 3years old.2.There is a certain relationship between immune dysfunction and the pathogen species of infection.3.The immune dysfunction of children with bronchopneumonia is related to the severity of the disease.4.Children with bronchopneumonia by wheezing symptoms have immune dysfunction. |
PDF Full Text Request