Analysis Of Clinical And Endoscopic Features Of Map-like Redness And Its Relationship With Early Gastric Cancer

Background and AimThe gastric map-like redness described in Kyoto Classification of Gastritis is a characteristic endoscopic feature after eradication of Helicobacter pylori(H P).The aim of this study was to investigate whether the map-like redness is risk factor for gastric cancer after successful eradication of HP,and further ana lysis of independent risk factors that lead to map-like redness.MethodsA retrospective analysis for patients diagnosed as Helicobacter pylori-eradicated gastritis who underwent upper gastrointestinal endoscopy in The Gastr ointestinal Edoscopy Center of Shandong Provincial Qianfoshan Hospital affiliat ed to Shandong University from 2018-01-01 to 2019-04-30,the patients were d ivided into two groups according to whether exhibited endoscopic map-like red ness after eradication of HP.The differences in age,gender,Kimura-Takemoto atrophy classification,Xanthoma,early gastric cancer and precancerous lesions were analyzed.To investigate the clinical and endoscopic features of patients with map-like redness,and the relationship between map-like redness and gastri c cancer after successful eradication of HP.ResultsThe two groups of patients who were included in the study were 84 cases in the map-like redness group and 82 cases in the non-map-like redness group.Univariate analysis showed that the increasing age,male gender,severe endoscopic atrophy,Xanthoma,early gastric cancer and precancerous lesions were significantly associated with the Map-like redness endoscopic feature(P=0.008,P=0.024,P=0.001,P=0.048,P=0.01).Multivariate analysis showed that age(p value for trend,0.013),male gender(OR2.698,95%CI[1.203-6.047],P=0.016),Kimura-Takemoto atrophy classification(p value for trend,0.002),and Xanthoma(OR7.558,95%CI[1.464-39.024],P=0.016)were independent risk factors for map-like redness after HP eradication.And the possibility of map-like redness increases along with the increasing age after HP eradication(<50y,Ref;50-69y,OR3.818,95%CI[1.449-10.062],P=0.007;>=70y,OR5.463,95%CI[1.464-20.377],P=0.011),as the degree of endoscopic atrophy increases,the possibility of map-like redness after HP eradication increases(CI,Ref;C-?,OR6.994,95%CI[2.224-21.993],P=0.001;C-?,OR7.209,95%Cl[2.086-24.919],P=0.002;O-?,OR53.902,95%CI[5.097-570.047],P=0.002).The map-like redness is independently related to gastric cancer or precancerous lesions(OR4.066,95%CI[1.375-12.023],P=0.011).The map-like redness may be an independent risk factor for primary gastric cancer after eradication of HP.Conclusionsage,male gender,Kimura-Takemoto atrophy classification,and Xanthoma are independent risk factors for map-like redness after successful HP eradicatio n,Furthermore,as the age or the degree of endoscopic atrophy increases,the r isk ofmap-like redness after HP eradication increases.The map-like redness ma y be anindependent risk factor for primary gastric cancer after eradication of H P.In addition,comprehensive and quantitative analysis of age,gender,Kimura-Takemoto atrophy classification and Xanthoma before HP eradication is helpful to assess the risk of map-like redness which was the extensive and severe int estinal metaplasia before HP eradication.