Sleep Characteristics Of Patients With Mild Cognitive Impairment And Its Correlation With Cognitive

BackgroundMild cognitive impairment(MCI),as a pre-dementia stage,does not affect the ability of daily living,and has a higher proportion of progress to various types of dementia.In addition to the symptoms of cognitive decline,there are also some patients with sleep disorders that reduce the quality of life and increase cognitive impairment.Patients with mild cognitive impairment have longer sleep latency and lower sleep efficiency than healthy people.ObjectiveTo study the structural characteristics of sleep,the types of sleep disorders and their effects on cognitive function in patients with different subtypes of mild cognitive impairment.MethodsA total of 50 patients with mild cognitive impairment and healthy groups in the Department of Neurological Memory Disorders and Inpatients of Guangdong Provincial People’s Hospital were collected.The MCI components were aMCI and naMCI.Patients were assessed for cognitive function,mood,sleep scale,sleep respiration monitoring and statistical analysis using SPSS 20 software.Results(1)There were no significant differences in age,education level,and BMI index among the NC group,aMCI group,and naMCI group(P>0.05).The MMSE and MOCA scores of NC group were higher than those of aMCI group and naMCI group(P<0.05).);(2)Sleep disordered breathing(SDB)and insomnia have the highest frequency of sleep disorders in aMCI group and naMCI group;(3)PSQI and ESS scores of aMCI group and naMCI group were higher than those of NC group,and sleep efficiency and nocturnal dysfunction scores of naMCI group were higher than those of NC group and aMCI group(P<0.05)(4)The proportion of people with sleep efficiency lower than 85%and the proportion of people with AHI>5 in the aMCI and naMCI groups was higher than that in the NC group.In the naMCI group,the proportion of N2 sleep was higher than that in the NC group and aMCI group,the proportion of N3 sleep was lower than that in the NC group;In the aMCI group,the proportion of N1 sleep was higher than that in the NC group,the proportion of REM sleep was lower than that in the NC and naMCI group;(5)The scores of PSQI and ESS scale in two MCI subgroups were negatively correlated with the scores of MMSE and MOCA scale respectively;(6)In the aMCI group,the N1 sleep proportion was negatively correlated with MOCA and MMSE scores,abstraction ability and delayed recall ability,while the REM sleep proportion was positively correlated with MMSE and MOCA scores,language function,delayed recall function,attention and abstraction ability;(7)The percentage of sleep in the N2 stage of the naMCI group was significantly negatively correlated with MMSE,MOCA scale scores,attention,abstract ability,visual space,and delayed recall.The proportion of sleep in the N3 stage was related to MOCA,MMSE,attention,abstract ability,delayed recall,Visual spatial ability was significantly positively correlated,and the proportion of sleep during REM was significantly positively correlated with MOCA,language function,and delayed recall.Conclusion(1)MCI patients have a higher prevalence of sleep disorders and a worse subjective sleep experience,and their objective examinations suggest that there are disturbances in sleep structure,low sleep efficiency,and a decrease in the proportion of deep sleep and REM sleep.(2)The aMCI patients showed an increase in the proportion of N1 sleep and a decrease in the proportion of REM sleep,and naMCI patients showed an increase in the proportion of N2 sleep and a decrease in the proportion of N3 sleep,and this change in sleep may be a sleep sign for cognitive decline.(3)The subjective sleep score and proportion of sleep stages of MCI population showed a moderate correlation with cognitive function,suggesting that the worse the sleep status may lead to the worse cognitive function.