| [Objective]Observe the effect of systemic lupus erythematosus(SLE)on blood glucose and blood lipid after long-term use of hydroxychloroquine.[Methods]Collected in the Department of Dermatology and Venereology of the Second Affiliated Hospital of Kunming Medical University from December 2013 to January 2020,and met the American College of Rheumatology(ACR)2009 SLE diagnostic criteria(Appendix 1),and the medical history was two years or more Of patients.The collected cases were screened,and patients with dynamic monitoring of blood glucose and blood lipid-related laboratory data 4 times(each interval of 1-2 months)and glycated hemoglobin 1 time were selected.According to the presence or absence of hydroxychloroquine(0.2g Po Bid),patients were divided into a study group(take hydroxychloroquine)and a control group(not take hydroxychloroquine).Among them,patients who monitored blood glucose and blood lipid data for 4 times may affect blood glucose and blood lipid.Relevant factors:gender,age,ethnicity,past history and family history:high blood pressure and/or hyperglycemia,use of drugs:lipid-lowering drugs and/or hypoglycemic drugs,using mixed effects model statistical methods to control influencing factors Comprehensive analysis;glycated hemoglobin data using t test and single factor linear regression analysis.[Results]1.General condition of SLE patients in this study:From December 2013 to January 2020,296 patients were diagnosed with SLE in the Department of Dermatology and Venereology of the Second Affiliated Hospital of Kunming Medical University,including 36 males and 260 females.The ratio is 1:7.22,the average male is 43.98±15.90 years old,the female average is 42.28±14.51 years old,and the number is 32-50 years old.133 patients in the study group,16 men(12.03%),117 women(87.97%);163 patients in the control group,20 men(12.27%),143 women(87.73%);have a history 125 patients with blood pressure and?or?hyperglycemia),18 males(14.40%),107 females(85.60%);53 patients with family history(hypertension and ?or?hyperglycemia),4 males(7.55%),49 women(92.45%);129 patients using hypoglycemic and lipid-lowering drugs,17 men(13.18%)and 112 women(86.82%).2.The effect of hydroxychloroquine treatment on TC:The average value of the study group in the four measurements is lower than that of the control group,and P?0.0001,the difference is statistically significant;the average value of TC in all SLE patients will decrease with time,But P?0.05,the difference is not statistically significant;with the increase of the number of measurements,the difference between the average value of the study group and the control group increases by-0.0563mmol/L each time,but P?0.05(P=0.4623),The difference was not statistically significant.3.The effect of hydroxychloroquine treatment on TG:The average value of the study group in the four measurements is lower than that of the control group,and P?0.0001,the difference is statistically significant;the average value of TG in all SLE patients will decrease with time,However,P?0.05,the difference was not statistically significant;with the increase of the number of measurements,the difference between the average value of the study group and the control group increased by-0.1191 mmol/L each time,P=0.0459?0.05,the difference was statistically significant significance.4.The effect of hydroxychloroquine treatment on HDL-C:The average value of the four measurements in the study group is lower than that of the control group,but P?0.05,the difference is not statistically significant;the average value of HDL-C in all SLE patients will change over time Increased,but P?0.05,the difference was not statistically significant;with the increase in the number of measurements,the difference between the average value of the study group and the control group increased by 0.0153 mmol/L each time,but P?0.05(P=0.4996),the difference was not statistically significant.5.The effect of hydroxychloroquine treatment on LDL-C:The average value of the four measurements in the study group was lower than that of the control group,and P?0.0001,the difference was statistically significant;There is a decrease,but P?0.05,the difference is not statistically significant;with the increase of the number of measurements,the difference between the average value of the research group and the control group increases by-0.0575mmol/L each time,but P=0.3392?0.05,The difference was not statistically significant.6.The effect of hydroxychloroquine treatment on FBG:The average value of the four measurements in the study group is lower than that of the control group,and P?0.05,the difference is statistically significant;the average value of FBG in all SLE patients will decrease with time,However,P?0.05,the difference was not statistically significant;with the increase of the number of measurements,the difference between the average value of the study group and the control group increased by-0.0435 mmol/L each time,P=0.4625?0.05,the difference was not statistically significant significance.7.The effect of hydroxychloroquine treatment on HbAlc:t test result:the glycated hemoglobin of the study group was significantly smaller than the control group,P=0.001?0.05,the difference was statistically significant;the result of linear regression:the change of hydroxychloroquine on glycated hemoglobin was 20.6%Affected,and the glycated hemoglobin value of patients in the hydroxychloroquine group will be reduced by an average of 1.64%,P=0.001?0.05,the difference is statistically significant.[Conclusions]1.Hydroxychloroquine can reduce TC,LDL-C,and FBG in patients with SLE,and all reach the maximum peak of the reducing effect within 3 months of the drug,and it will be stable after reducing to the normal range.2.Hydroxychloroquine can reduce triglycerides in patients with SLE,and the maximum peak of TG reduction will only appear after the administration of hydroxychloroquine for more than 6 months.3.Hydroxychloroquine will not reduce high-density lipoprotein cholesterol in patients with SLE,and will not affect with the prolonged administration of hydroxychloroquine.4.Hydroxychloroquine can reduce the value of glycated hemoglobin in patients with SLE... |
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