Resting State-functional Magnetic Resonance Imaging Independent Component Analysis And Cerebral Cortex Morphology Study Of First Episode Major Depressive Disorder

Part Ⅰ Independent component analysis of the first episode untreated resting state fMRI for major depressive disorderObjective:Functional magnetic resonance imaging(fMRI)was used to perform an independent component analysis(ICA)of the brain for the first episode of untreated major depressive disorder in the resting state to further explore the brain functional state of depression.Methods:15 patients with first-episode major depressive disorder who were not medicated[live up to DSM-Ⅳ diagnostic criteria for depression,they met the Hamilton depression scale(HAMD-24)score of 24～43]and 15 matched healthy controls were collected for fMRI scanning under resting state.ICA was used to statistically analyze the differences in brain areas between the two groups.Results:The bilateral superior frontal gyrus,bilateral middle frontal gyrus,bilateral middle temporal gyrus,left precuneus,left anterior cerebellum,bilateral posterior central gyrus,bilateral cingulate gyrus,bilateral superior parietal lobule,bilateral inferior parietal lobule and other brain areas in the depression group under resting state were significantly activated and were higher than the healthy control group(P<0.05,K>10).Conclusions:Activation changes in different brain regions of patients with depression further reflect the relationship between the emotional state of depression and various functional networks in the brainPart Ⅱ Morphology studies of the cerebral cortex in patients with first-episode untreated major depressive disorderObjective:With the development of cognitive psychology and neuroimaging,this paper discusses how depression affects the cerebral cortex structure of first-episode untreated patients,and provides new imaging basis for the etiology and treatment of depressionMethods:24 first episode of major depressive disorder(MDD)[live up to DSM-Ⅳ diagnostic criteria for depression,they met the Hamilton depression scale(HAMD-24)score of 24～43]and 24 matched cognitively normal(CN)subjects received resting-state functional magnetic resonance imaging(rs-fmri)and neuropsychological tests.We used Freesurfer software to compare the morphological parameters of cerebral cortex such as thickness,area,volume,curvature and sulcus between MDD group and CN group.GLM and monte carlo simulation multiple comparison correction were used to analyze the statistical results.Results:Compared with the CN group,the thickness of cerebral cortex in the MDD group decreased in the anterior central area of both hemispheres and the superior parietal lobe of the left hemisphere,while the volume of cerebral cortex in the MDD group decreased in the anterior central area of both hemispheres and the lateral occipital area of the right hemisphere.Conclusions:The thickness and volume of cerebral cortex of patients with first-episode untreated major depression were different in multiple brain regions,which further provided objective imaging basis for the etiology and treatment of depression.