Study On The Association Between Plasma Fibrinogen Level And Clinicopathological Characteristics Of Patients With Prostate Cancer

Background and objectiveProstate cancer is the malignant tumor with the highest incidence and the second highest mortality in men in Europe and the United States.In recent years,the incidence of prostate cancer has been increasing year by year in China,ranking the first place in the incidence of urogenital cancer in men over the age of 70,which seriously threatens the health of middle-aged and elderly men.As the population ages,prostate cancer will become a heavy burden on public health expenditure in China The characteristics of prostate cancer vary significantly among races,regions and individuals.The causes of prostate cancer are not completely clear.In addition to age,genetics,and race,diet and lifestyle habits(including lack of physical activity,excess energy,and excessive animal fat intake)have become independent risk factors for occurrence and progression of prostate cancer.At the present,the indicators applied in the diagnosis and disease evaluation of prostate cancer cannot meet the clinical requirements well.Therefore,it is of great clinical significance for clinical decision-making and subsequent diagnosis and treatment of patients with prostate cancer to explore the markers with predictive value for the diagnosis and disease progression of prostate cancer to identify high-risk patients.Previous studies have shown that fibrinogen is not only involved in coagulation,but also significantly increased in patients with malignant tumors,which is closely related to the occurrence and development of tumors.The purpose of this study was to analyze the relationship between preoperative plasma fibrinogen levels and the clinicopathological features of prostate cancer,and to explore its value in the diagnosis and the prediction of disease progression of prostate cancer.MethodsA retrospective analysis of clinical and pathological data from 456 patients with prostate cancer(PCa)and 322 benign prostatic hyperplasia(BPH)patients who met the study criteria from January 2006 to December 2017 was performed.The age,body mass index(BMI),fibrinogen(FIB),Gleason score,total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),free prostate specific antigen percentage(f/tPSA),clinical T stage(cT),presence or absence of lymph node metastasis,presence or absence bone metastasis and risk stratification were collected and were analyzed.SPSS 19.0 software package was used to analyze the correlation between the fibrinogen and the above indexes.ResultsThe preoperative plasma median FIB in PCa group and BPH group were 3.52 g/L(IQR,2.97-4.35)and 3.12 g/L(IQR,2.61-3.45),respectively.The plasma FIB was significantly increased in patients with PCa compared to patients with BPH(P<0.05).In patients with PCa,the level of fibrinogen was related to PSA,Gleason score,clinical T stage,risk grade and age(P<0.05).The preoperative plasma fibrinogen level was significant positively correlated with age,tPSA,Gleason score,clinical T stage(P<0.05)ConclusionPreoperative plasma fibrinogen level in patients with prostate cancer was associated with tumor pathological score,clinical T stage and related serum indicators,which can be combined with relevant imaging and laboratory examination results to predict the disease progression and outcome of patients.And we recommend aggressive prostate biopsy for patients with suspected prostate cancer who have high plasma fibrinogen levels.